Course

Estimations

Estimation of – equivalent weight of an acid, glucose, phenol, acetone, acid value of an oil, iodine value and sap value of an oil, Nitrogen (Kjeldahl method), formaldehyde, aniline

Estimation of ester.

Estimation of the following drugs: Aspirin (titrimetry), Ibuprofen (titrimetry),Analgin (titrimetry), ascorbic acid {titrimetry (Iodometry and Cerimetry), colorimetry}, Riboflavin (colorimetry), Zn ions in Bacitracin Zinc, Ca⁺² ions in Calcium gluconate injection (complexometry), Diazepam (UV-Visible Spectrophotometer).

1. Preparations of Organic Compounds Double stage preparations:
2. m-nitro benzoic acid from ethyl benzoate
3. p-bromobenzanilide from aniline
4. p-nitro acetanilide from aniline

Single stage preparations:

1. Benzimidazole
2. Benzophenone oxime
3. Dibenzilidene acetone (chalcone)
4. Benzalacetophenone
5. Benzanilide
6. Acetanilide
7. Acetyl salicylic acid (aspirin)

Name Reactions:

1. Benzil-Benzilic acid rearrangement
2. Cannizaro reaction
3. Claisen condensation

Identification of unknown organic compounds from their IR, UV,1H NMR and Mass Spectral data: Analysis of recorded spectra of compounds belonging to i) alkynes, ii) alcohols and phenols iii) aldehydes and ketones iv) carboxylic acids,v) esters vi) acid amides and vii) primary and secondary amines.

For all preparations

1. TLC to be done and Rf values of each compound to be reported
2. Melting point of pure compounds to be found
3. A small portion should be recrystallized from suitable solvent
4. Purified products to be displayed
5. Mechanisms for each preparation should be suggested

References

1. W.G. Smith, A.J. Hannaford, B.S. Furnis and A.R. Tatchell, “Vogel’s Textbook of Practical Organic Chemistry”, ELBS/Longman, 1989.
2. Ralph L. Shriner, Christine K. F. Hermann, Terence C. Morrill, David Y. Curtin, Reynold C. Fuson, ‘Systematic Identification of Organic Compounds’, John Wiley & Sons, 2003.
3. Mann and Saunders, ‘Practical Organic Chemistry’, Pearson edition, 2009.