Unit 1
Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases
| Course Name | Biochemistry Lab |
| Course Code | 24MMD583 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Faridabad, Kochi |
Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases
The process of growth, differentiation and cell death and its molecular organization in cellular homeostasis and diseases such as cancer, neurodegenerative diseases and diabetes. Significance of molecular changes in controlling a normal homeostasis condition compared to disease.
Pathological changes in diseases such as cancer, neurodegenerative diseases, autoimmune diseases and diabetes. The role of molecules and molecular changes in the pathological manifestation of disease.
Significance of environmental chemicals in modifying normal homeostasis and leading to pathological changes at molecular level by controlling different signaling mechanisms. Significance of epidemiology, etiology in pathogenesis of diseases
Inflammation in normal and pathological state. Molecular mechanisms driving the immunopathology in cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Interdependence of molecular pathways in controlling homeostasis and disease pathology
How the molecular changes can be targeted to reverse the pathology and the contribution of drugs in this respect cancer, neurodegenerative diseases, autoimmune diseases and diabetes.
DNA modifications and mutations in diseases and its significance in the pathology associated with cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Role of environment in (lifestyle) in modifying DNA and the molecular landscape associated with homeostasis and disease in cancer, neurodegenerative diseases, autoimmune diseases and diabetes.
Pre-requisites: Basic understanding of biology and chemistry
Total number of classes: 30
Course Outcome
CO1: Understand the basics of the measure of solution concentration
CO2: Understand the importance of protein estimation, different types of protein estimation (Eg., Lowry method, Biuret method etc)
CO3: Understand how to quantify enzyme level in serum (amylase enzyme)
CO4: Determine the presence of amino acids in a given sample and know the advantages / disadvantages of different method of detection.
CO5: Evaluate separation of proteins in the sample by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and chromatographic techniques
Program outcome
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
|
|
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
CO1 |
3 |
3 |
2 |
1 |
1 |
– |
– |
2 |
3 |
2 |
– |
2 |
|
CO2 |
3 |
3 |
2 |
1 |
1 |
– |
– |
2 |
3 |
2 |
– |
2 |
|
CO3 |
3 |
3 |
2 |
1 |
1 |
– |
– |
2 |
3 |
2 |
– |
2 |
|
CO4 |
3 |
3 |
2 |
1 |
3 |
– |
– |
2 |
3 |
2 |
– |
2 |
|
CO5 |
3 |
3 |
2 |
1 |
2 |
– |
– |
2 |
3 |
2 |
– |
2 |
Program Specific Outcomes (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
|
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
|
|
CO1 |
– |
2 |
– |
– |
– |
– |
– |
– |
– |
– |
|
CO2 |
1 |
2 |
2 |
2 |
– |
– |
– |
– |
– |
– |
|
CO3 |
1 |
2 |
2 |
2 |
– |
– |
– |
– |
– |
– |
|
CO4 |
1 |
2 |
2 |
2 |
– |
– |
– |
– |
– |
– |
|
CO5 |
1 |
2 |
2 |
2 |
– |
– |
– |
– |
– |
– |
Evaluation Pattern: 30+70 = 100
|
Internal Assessment – 30% |
||
|
Records |
Evaluation |
30% |
|
30% |
||
|
End Semester Examination- 50% |
||
|
Practical |
Exam |
60% |
|
Assessment |
Viva |
10% |
|
70% |
||
|
Total |
100% |
|
Robbins Basic Pathology, 9th edition, Kumar, Abbas, Fausto and Mitchell; Saunders, Publication, ISBN-13: 978-1437717815. ]
Selected research articles will be provided before each class
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