Qualification: 
M. Pharm.
sreejacnair@aims.amrita.edu

Ms. Sreeja C. Nair joined as Lecturer in Department of Pharmaceutics, Amrita School of Pharmacy in September 2012. She completed her Bachelor’s degree from Cherran’s College of Pharmacy and Master’s degree in Pharmaceutics from Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham. Currently she serves as Assistant Professor. She has over 5 yrs experience in both teaching and industry. Currently, she is guiding B.Pharm and M.Pharm students. Her areas of interest include formulation, development and drug design. She has around 38 international publications to her credit.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

K. Ramesh, Krishnapriya, M., Paul, A., and Nair, S. C., “Preparation and evaluation of chitosan sodium alginate carbamazepine microspheres”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 271-276, 2017.[Abstract]


Objective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres for the purpose of controlled release for the treatment of epilepsy to avoid the possible side effects. Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into the natural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies. Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within the acceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation (CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy. Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery. © 2017 The Authors.

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2017

Journal Article

M. Krishnapriya, Ramesh, K., and Nair, S. C., “Antiepileptic rectal hydrogel loaded with carbamazepine – Rice bran wax microspheres”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 264-270, 2017.[Abstract]


Objectives: The objective behind the study is to develop a mucoadhesive rectal hydrogel from carbamazepine (CBZ) – rice bran wax (RBW) microspheres for the purpose of controlled release for the treatment of epilepsy. Methods: The study was conducted to formulate controlled release rectal hydrogel loaded with CBZ – RBW microspheres in two different natural polymers, RBW and collagen which are prepared by modified cooling induced solidification method and gel preparation along with their evaluation studies. Results: A thorough analysis of the optimized gel revealed that all the evaluation parameters evaluated are within the acceptable limits. Further, the optimized microsphere formulation (M5) was used to formulate it as rectal hydrogel using polymer collagen and was characterized. The mucoadhesion time of 25% w/w collagen hydrogel (H4) was 565 minutes, allowing the loaded microspheres to be attached on rectal mucosa. In vitro drug release from the mucoadhesive hydrogel formulations showed controlled drug release pattern with a maximum drug release of 96.45±0.35% for optimized H4 formulation after 12 hr, followed zero order release pattern with diffusion mediated Higuchi model. Ex vivo permeation studies using bovine rectal mucosa revealed that H4 formulation showed greater permeability compared to control. Histopathological findings revealed that H4 formulation is safer for rectal administration without any signs of rectal irritancy. The stability studies of optimized formulation (H4) proved that hydrogel remained stable over a wide range of temperature condition. Conclusion: Hence, the developed rectal hydrogel formulation seems to be a viable alternative to conventional drug delivery system for the effective management of epilepsy. © 2017 The Authors.

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2017

Journal Article

B. S. Kumar, Krishna, R., Lakshmi, P. S., Vasudev, D. T., and Nair, S. C., “Formulation and evaluation of niosomal suspension of cefixime”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 194-201, 2017.[Abstract]


Objectives: The present study was aimed to overcome the problems associated with the drug such as bioavailability, to reduce the dosage regimen, half–life, and to determine the appropriateness of niosomal formulation as a drug carrier. Methods: The niosomal suspension was prepared by thin film technique, by varying ratios of span 60 and cholesterol and varying the concentration of span 60. The prepared four formulations were evaluated for various parameters. Results: The optimized formulation had a vesicular size of 250-400 nm. Varying the concentration of span 60, the entrapment efficiency demonstrated that it had a considerable task. The highest entrapment efficiency was 95.3%. The kinetics study confirmed that the liberation of drug from the niosomal suspension is in a restricted manner. The statistical optimization showed that NS2 is the optimized formulation. The gastrointestinal enzymes showed no significant change in the release of drug from the formulation. The zone of inhibition showed that optimized formulation has a better activity than the marketed formulation. The MIC was found to be 0.05 mg, hence can be used as an efficient carrier for delivery of cefixime. Conclusion: The present study concludes that the prepared niosomal suspension is a convenient and efficiency carrier for the delivery of antibacterial drug. Besides this, it provided controlled delivery of drug. © 2017 The Authors.

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2016

Journal Article

T. Sasidharan and Nair, S. C., “Magnetic Microsphere: A Review”, Research Journal of Pharmacy and Technology, vol. 9, pp. 281-286, 2016.[Abstract]


Site-specific drug delivery plays important role in the delivery drug the targeted site for orally and parentral routes of administration. Microspheres constitute an important part of this particulate drug delivery system by virtue of their small size and efficient carrier characteristics. Magnetic microsphere has been alternatively traditional method for delivering drug.it is the newer approach in delivery of drug to the targeted site by reducing the amount of free drugs circulating in the whole body by reducing excess dose dumping and for limiting toxicity for reducing the side effects of the drug. The magnetic microspheres are delivered using an external magnetic energy to help reach the carrier to the targeted site. the aim of the present study was to investigate overview of the size, properties, mechanism, benefits, drawbacks, different preparation and applications of magnetic microspheres. © RJPT All right reserved. More »»

2016

Journal Article

K. M. Fathima, Nitheesh, A., Paul, A., and Nair, S. C., “Sphingosome vescicular system”, International Journal of Pharmaceutical Sciences Review and Research, vol. 41, pp. 208-213, 2016.[Abstract]


Vesicular drug delivery system has overtaken the pre existing drugs by improving therapeutic efficacy and by sustaining and controlling action. Liposomes, herosomes, sphingosomes, ethosomes, cubosomes, pharmacasomes, niosomes, transferosomes are the newly developed vesicular drug delivery system. This article mainly deals with the sphingosomal drug delivery system. It provides a brief description about advantages and disadvantages of sphingosomes, the main classification of sphingosomes and highlights about its applications. Sphingosomes are vesicular drug delivery system which is made up of a lipid bilayer membrane enclosing an aqueous volume. Because of its wide variety of application in treatment of cancer, cosmetics, gene delivery, ocular drug delivery; it has become a better area of field of study. These systems have enhanced therapeutic index of all drugs by encapsulating these medications inside aqueous volume. © 2016, International Journal of Pharmaceutical Sciences Review and Research.

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2014

Journal Article

Sreekumaran A Nair, Vidhya, K. M., Saranya, T. R., Sreelakshmy, K. R., and Nair, S. C., “Mucoadhesive buccal patch of Cefixime trihydrate using biodegradable natural polymer”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, pp. 366-371, 2014.[Abstract]


Objective: The objective behind the study was to develop a bio erodible mucoadhesive buccal patch containing Cefixime trihydrate as a therapeutic agent for the treatment of bacterial infections and their evaluation. Methods: Cefixime trihydrate buccal patches were prepared by solvent casting method. Results: The formulated patches were subjected to various evaluation parameters and all the physical parameters evaluated are within the acceptable limits. The formulation F5 showed maximum release 98.1% while other formulations showed less amount of drug release in 7 hr. The in vitro antibacterial activity by agar diffusion assay demonstrated a significant antibacterial profile of the optimized patch F5 against Streptococcus species. The morphological study by Scanning electron microscopy (SEM) confirmed that the upper surface of patch containing Cefixime (F5) was rough with numerous pores inside it. The stability study proved that the formulation F5 was found to be stable. Conclusion: The prepared formulation also provides a desired antimicrobial sustained drug delivery into the systemic circulation.

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2014

Journal Article

S. C. Nair and Anoop, K. R., “Design and in vitro evaluation of controlled release Satranidazole subgingival films for periodontitis therapy”, International Journal of Pharmaceutical Sciences Review and Research, vol. 24, pp. 8-14, 2014.

2014

Journal Article

S. C. Nair, John, M. S., and Anoop, K. R., “In situ gel: An innovative approach for safe and sustained nasal drug delivery”, International Journal of Pharmaceutical Sciences Review and Research, vol. 24, pp. 1-7, 2014.

2013

Journal Article

S. C. Nair and Anoop, K. R., “Local antimicrobial delivery of Satranidazole loaded cross linked periodontal chips using bio degradable polymers”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, pp. 839-847, 2013.[Abstract]


Objective: The goal in using a local nonsurgical controlled intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Methods: The study was conducted to fabricate a bio erodible delivery system for Satranidazole, dispersed in two different polymers, natural Chitosan and semi synthetic HPMC polymers by simple casting method. The prepared chips were cross linked with glutaraldehyde 2 and 4 %v/v for 1, 2, 3 and 4 hours for extended release. Results: All chips prepared have good physicochemical properties. Static dissolution studies showed a burst release initially followed by a slow sustained release when cross-linking was attempted. The percentage cumulative drug release was greater in chitosan than HPMC. In vitro release and permeation Kinetics showed zero order profile. The cross linked formulations C52C3 and H52C1 are better than others because the extent of release was maintained for 8 and 6 days respectively. Histopathological studies of the periodontal mucosa suggested that the formulations were safe for local anti microbial treatment in to the infected periodontal pocket. The optimized formulation C52C3 showed highest mucosal permeation of Satranidazole and greater growth inhibition area for Porphyromonas gingivalis. Scanning electron microscopy showed that the upper surface of cross linked chips was smooth.The stability studies did not show any significant changes. Conclusion: The findings of the results easily predict the fact that chitosan and HPMC can be used to prepare chip utilizing the anti microbial property of Satranidazole for treating periodontitis.

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2013

Journal Article

M. S. John, Nair, S. C., and Anoop, K. R., “Thermoreversible mucoadhesive gel for nasal delivery of anti hypertensive drug”, International Journal of Pharmaceutical Sciences Review and Research, vol. 21, pp. 57-63, 2013.[Abstract]


The present study was aimed to develop a mucoadhesive in-situ gel of Carvedilol for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. Carvedilol was incorporated into the blends of thermoreversible polymer pluronic F 188(PF 188) and bioadhesive polymer Carbopol 940 in the form of in-situ gel by cold technique to reduce the muco ciliary clearance, and thereby it will increase the contact of formulation with nasal mucosa and hence improving drug absorption. The prepared gels were characterized by Gelation temp, pH, Drug content, Gel strength, permeation studies, Histopathological evaluation, stability study etc. The results revealed that as the concentration of Carbopol increases there was a decrease in the gelation temperature. pH of all the formulations were found to be within the range between 4.5-6.0 and the nasal mucosa can tolerate the above mentioned pH of the formulations. The drug content of all formulations was found to be 97.44 to 99.17%. Tests also revealed that as the level of carbopol increases mucoadhesive strength also increase. Viscosity measurement of the formulations at temperatures 25°C & 37°C, shows that there was increase in viscosity with increase in the temperature and it was found that all formulations were in liquid state at room temperature and were converted into gel at nasal physiological temperature. The optimized formulation showed a drug release of 93.98% in 480 min. The biopolymers used and their compositions in the in-situ gels preparation greatly affected the drug release which allows absorption in the nasal mucosa.

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2013

Journal Article

M. N. Anjana, Jipnomon Joseph, and Nair, S. C., “Solubility enhancement methods -a promising technology for poorly water soluble drugs”, International Journal of Pharmaceutical Sciences Review and Research, vol. 20, pp. 127-134, 2013.[Abstract]


The most challenging task in drug development is enhancement of solubility, dissolution rate, and bioavailability of drug. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Drug to be absorbed should be in solution form at the site of absorption. Absorption of orally administered drugs will take place only when they show fair solubility in gastric medium and such drugs show good bioavailability. Solubility and dissolution properties of drugs play an important role in the process of formulation and development. Major challenge for formulation scientist is the solubility problem which can be solved by different technological approaches during the pharmaceutical product development work. This review gives detailed information about various technologies used for enhancing solubility and dissolution of poorly soluble drugs, including nanotechnology methods for enhancing solubility to reduce the percentage of poorly soluble drug candidates eliminated from the development. Selection of this solubility enhancing method mainly depends on drug property, site of absorption and dosage form characteristics.

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2012

Journal Article

S. C. Nair and Anoop, K. R., “Intraperiodontal pocket: An ideal route for local antimicrobial drug delivery”, Journal of Advanced Pharmaceutical Technology and Research, vol. 3, pp. 9-15, 2012.[Abstract]


Periodontal pockets act as a natural reservoir filled with gingival crevicular fluid for the controlled release delivery of antimicrobials directly. This article reflects the present status of nonsurgical controlled local intrapocket delivery of antimicrobials in the treatment of periodontitis. These sites have specialty in terms of anatomy, permeability, and their ability to retain a delivery system for a desired length of time. A number of antimicrobial products and the composition of the delivery systems, its use, clinical results, and their release are summarized. The goal in using an intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Novel controlled drug delivery system are capable of improving patient compliance as well as therapeutic efficacy with precise control of the rate by which a particular drug dosage is released from a delivery system without the need for frequent administration. These are considered superior drug delivery system because of low cost, greater stability, non-toxicity, biocompatibility, non-immunogenicity, and are biodegradable in nature. This review also focus on the importance and ideal features of periodontal pockets as a drug delivery platform for designing a suitable dosage form along with its potential advantage and limitations. The microbes in the periodontal pocket could destroy periodontal tissues, and a complete knowledge of these as well as an ideal treatment strategy could be helpful in treating this disease.

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Faculty Research Interest: 
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