Qualification: 
Ph.D, M. Pharm.
Email: 
vidyaviswanad@aims.amrita.edu

Dr. Vidya Viswanad joined as Assistant Professor at Amrita School of Pharmacy in July 2008. Currently she serves as Associate Professor in Department of Pharmaceutics. She completed her B. Pharm and M. Pharm from Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore. She received her Ph. D. from Vinayaka Missions University, Salem in the year 2014. She  has about 13 years of teaching experience and has more than 22 national and international publications to her credit. Her main area of  interests are novel drug delivery systems for targeted drug release, in the areas of rheumatoid arthritis and topical skin diseases.. She has worked as a co-investigator in a project funded by Coconut Development Board and 3 of her M. Pharm research projects were funded by Kerala State Council for Science and Technology.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

K. Pa Reshmi, Dr. Subin Mary Zachariah, and Dr. Vidya Viswanad, “Formulation and evaluation of novel chromene derivative as an anti-inflammatory agent used for inflammatory bowel diseases”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 319-324, 2017.[Abstract]


Objective: To formulate and evaluate an extended-release (ER) tablet of a new molecule, 2-amino-4-(4-bromophenyl)-7-hydroxy-4H-chromene-3-carbonitrile using a combination of two polymers (hydroxypropyl methyl cellulose [HPMC] K100 and HPMC phthalate) which control the rate and degree of the drug release through 12 hrs period and protect the drug release from acidic pH. Methods: Five batches of tablets (4HC1, 4HC2, 4HC3, 4HC4, 4HC5) were produced by direct compression method. Morphological evaluation of the powder blend was carried out by differential scanning calorimetry and Powered X-ray diffractometry. The evaluation studies such as flow properties, hardness, friability, drug content, and release study were conducted according to pharmacopoeial standards. Results: The physicochemical characteristics of all the granules and tablets were generally satisfactory. The drug release followed zero order, Higuchi model kinetics with diffusion and dissolution mediated mechanism. Tablets were evaluated for physicochemical parameters and promising. Stability studies indicated the dosage form is stable for 3 months at accelerated conditions. Conclusion: From the results received from all test, it was concluded that formulation 4HC4 are the most suitable choice for developing 12 hrs ER tablets. This finding reveals that a particular concentration of HPMC K100 was capable of producing ER. © 2017 The Authors.

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2017

Journal Article

P. Shammika, Dr. Aneesh T. P., and Dr. Vidya Viswanad, “Formulation and evaluation of synthesized quinazolinone derivative for colon specific drug delivery”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 207-212, 2017.[Abstract]


Objective: The current research deals with the formulation and evaluation of synthesized quinazolinone derivative for colon site specific delivery. Methods: The synthesized quinazolinone derivative was enteric coated 5% Eudragit L-100 with by wet granulation method using guar gum, pectin, and guar gum pectin combination as hydrophilic polymer. The prepared matrix tablet was characterized by differential scanning calorimetry and evaluated for different pre-compression and post-compression studies and drug release profiles. Results: All the matrix tablets were within the range of pharmacopeial limits with better flow properties. All the six formulations of matrix tablets had disintegrated within 5-6 minutes. The optimized formulation selected was F6 formulation combination of guar gum and pectin with 95.79% of drug release than compared to the remaining formulation. The optimized matrix tablets followed zero order kinetics with Fickian diffusion. Conclusion: The results proposed that the combination of guar gum and pectin coated tablet with 5% Eudragit L-100 of synthesized quinazolinone derivative is a promising colon site specific delivery. © 2017 The Authors.

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2017

Journal Article

S. Aiswarya, Parvathy, S., Dr. Aneesh T. P., and Dr. Vidya Viswanad, “Design and in vitro characterization of metformin loaded resealed erythrocytes”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 231-238, 2017.[Abstract]


Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation. Methods: The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation of the drug metformin. Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive. Conclusion: The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin. © 2017 The Authors.

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2015

Journal Article

Dr. Vidya Viswanad, Zachariah, S. Ma, Sathi, Aa, and Aleykutty, N. Ab, “Development of phytovesicles containing triterpenoids from Samadera indica”, Pharmacognosy Research, vol. 7, pp. 176-183, 2015.[Abstract]


Introduction: Samadera indica belonging to Simaroubaceae family is being used traditionally for many diseases including arthritis, edema, itching, skin diseases, constipation, and general debility. Objective: The effectiveness of any drug delivery system depends upon its ability to deliver the active components at therapeutic level. In this study, a novel phyto vesicular formulation for the enhanced topical delivery of methanol extract of S. indica in order to treat skin infections was developed. Materials and Methods: The methanol extract fraction of leaves of S. indica which showed more antifungal activity was purified to separate an antifungal compound. Phytovesicles were formulated using the more antifungal fraction in order to treat topical and deep seated fungal infections. Pytovesicles were prepared using 1:2 molar ratio of antifungal triterpenoid from S. indica (AFTSI)-phosphatidylcholine by film hydration method. Results and Discussion: Chloroform 100% fraction of methanol extract of S. indica showed more activity against the fungus Candida albicans. Further purification gave a fraction with minimum inhibitory concentration value of 15.6 mg/ml against C. albicans and showed positive test for triterpenoids. The fraction was named as AFTSI. A compound (20 mg) was isolated from this fraction at an R F value. The phytovesicle gel formulated using AFTSI showed enhanced skin permeability and antifungal activity. Conclusion: The study demonstrated that the phytovesicular gel developed using methanol extract of S. indica would be beneficial for treating deep seated fungal infections. © 2015, Medical Knowledge. All rights reserved.

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2012

Journal Article

Dr. Subin Mary Zachariah, Dr. Vidya Viswanad, Aleykutty, N. Ab, Jaykar, Bc, and Halima, O. Aa, “Free radical scavenging and antibacterial activity of Mirabilis jalapa Linn using in vitro models”, Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 115-120, 2012.[Abstract]


Medicinal plants form a major source of raw materials for drugs for the prevention and treatment of ailments. Mirabilis jalapa linn is used as antinociceptive, anti-inflammatory agent, laxative in folk medicine. Antioxidants play an important role in protecting against damage by reactive oxygen species.The present study was designed to evaluate the plant potential as an antioxidant lead by using various in vitro models like Hydrogen peroxide scavenging method and reducing power assay method and also to determine its antibacterial potential. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, polyphenols like phenolic compounds and tannins. The total flavanoid content of the extract was found to be 4.41 ± 0.02 mg /gram. The plant exhibited significant antioxidant properties and could serve as a free radical inhibitor or scavenger. The antibacterial activity of the extracts was determined by the agar well diffusion method. The greatest zone of inhibition was displayed by methanolic extract against pseudomonas at 3mg/ml. With a wide spectrum of inhibition against Gram-positive and Gram-negative bacteria, the methanolic extract of Mirabilis jalapa are worthy of further investigation as a natural wide spectrum antibacterial agent. These results indicates the potential of Mirabilis jalapa as a source of antioxidant and antibacterial compound.

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2012

Journal Article

Dr. Subin Mary Zachariah, Aleykutty, Nb, Dr. Vidya Viswanad, and Halima, O. Aa, “An overview on hepatoprotective activity of natural products”, Research Journal of Pharmacy and Technology, vol. 5, pp. 317-321, 2012.[Abstract]


Medicinal practioners have prescribed Ayurveda and drugs from herbal origin as a system of medicine in India over centuries. Many of the modern drug mainly based on synthetic chemical compounds, however have been found to have harmful side effects on the human system. This has triggered off extensive research and development in the field of herbal medicine. In fact, there is a growing demand for herbal medicines in most of the developed and developing countries of the world today. Liver is a vital organ that plays a major role in the metabolism and excretion of xenobiotics from the body. Liver disease is the major challenge faced by the world and is the leading cause of death in western countries. Exposure too many chemicals such as carbon tetrachloride, thioacetamide, alcohols and drugs can result in injury to liver, therby impairing its normal function and resulting in biochemical abnormalities. Herbal drugs are the potential source of therapeutic aid for treating liver disease and a number of scientific investigations revealed the importances and contributions of these natural products. Numerous medicinal plants and their formulations are used for liver disorders in ethnomedical practice as well as traditional system of medicine in India. More over them are economical with fewer side effects and can be used independent of any age groups. They are rich in chemical compounds like flavonoids that impart antioxidant property and in turn possess hepatoprotective activity. Though a wide variety of herbal drugs with hepatoprotective activity is known, many of them are not proven clinically. The hepatoprotective activity of some herbal drugs clinically proven using hepatotoxicity models are explained in this review. This review is aimed at enumerating some of the natural products that possess hepatoprotective activity. © RJPT All right reserved.

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2011

Journal Article

Dr. Vidya Viswanad, Aleykutty, N. Ab, Dr. Subin Mary Zachariah, and Thomas, La, “Evaluation of antioxidant and free radical scavenging activity of Samadera indica using In vitro models”, Pharmacognosy Journal, vol. 3, pp. 85-90, 2011.[Abstract]


Antioxidant has gained importance in the current scenario as it has an ability to trap free radicals which are produced during the degenerative diseases. Natural antioxidant is considered superior to synthetic as it is safe and produces a prominent action. Samadera indica a bitter plant widely distributed throughout India, and mostly found in evergreen forest of Western Ghats and along river shore, the bitterness is due to the presence of flavanoids like Quassinoids. Literatures showed the presence of Quassinoids and therefore, plant may show the antioxidant activity which is not yet ruled out. Hence the present study was focused out to evaluate the antioxidant activity of Samadera indica by in-vitro models. Method: The plant leaf was extracted using methanol and acetone as solvent. The extracts were evaluated for antioxidant activity and free radical scavenging assay using DPPH, ABTS radical scavenging assay, FRAP, DCF/AAPH assay and was expressed as IC 50. Result: All the methods showed a prominent antioxidant activity butwere comparatively lower than standard Quercetin. Antioxidant activity of extracts produced increased scavenging activity in a dose dependent manner. Conclusion: The evaluation of antioxidant activity of Samadera indica concludes that the plant extracts showed activity and this may be due to the presence of flavanoids. Hence, further work should be done on the isolation and identification of other antioxidant components of Samadera indica.

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