Multifocal tuberculous osteomyelitis: Possible inherited interferon gamma axis defect
Publication Type:Journal Article
Source:Indian Journal of Pediatrics, Volume 80, Number 6, p.505-508 (2013)
Keywords:ankle edema, antibiotic agent, article, BCG vaccine, bone biopsy, bone radiography, case report, child, female, gamma interferon, human, human tissue, interferon production, interleukin 12, metacarpal bone, Mycobacterium tuberculosis, physical examination, polymerase chain reaction, preschool child, treatment outcome, treatment response, tuberculostatic agent, tuberculous osteomyelitis
Multifocal Tuberculous (TB) osteomyelitis is an extremely rare entity in immunocompetent individuals. The authors report a 19-mo-old girl with multifocal TB osteomyelitis which resolved completely following institution of four drug antituberculous treatment for 1 y and detailed immunological evaluation was found to be normal but as the response of interferon gamma (IFN γ) in terms of production of IL12p40 was severely impaired, she is suggested to have a possible defect in the interferon gamma axis even though the exact defect in the pathway could not be delineated. This case report reiterates the need for detailed immunological evaluation in children presenting with multifocal TB osteomyelitis. © 2012 Dr. K C Chaudhuri Foundation.
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