Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Source : Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Volume 48, Number 1, p.21-30 (2011)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-78649456732&partnerID=40&md5=c12fceb4e08411490bba9792d06f79c3
Keywords : adsorption, Apatite, Cell activity, Cell attachments, cell viability, Cells, Composite materials, Composites, Electrospinning, Electrospuns, Fibers, fibrous composite scaffold, Fibrous scaffolds, Hierarchical Systems, Hydroxyapatite, In-cell, Mechanical properties, Microfibers, Mixtures, Multiscales, Nano-hydroxyapatite, Nanofibers, Per unit, Polymer blends, Protein adsorption, Scaffolds, Spinning, Surface area, Time dependent, Tissue, tissue engineering, Tissue engineering applications, Total protein
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2011
Abstract : Electrospun nano, micro and micro/nano (multiscale) poly(caprolactone) (PCL) fibrous scaffolds with and without nano hydroxyapatite (nHAp) was prepared. All the scaffolds were evaluated for its spectroscopic, morphological, mechanical, thermal, cell attachment and protein adsorption properties. The cell attachment studies showed that cell activity on the nano-fibrous, as well as multi-scale scaffolds with and without nHAp was higher compared to micro-fibrous scaffolds. A time dependent cell attachment study on aligned micro-fibers was carried out to elucidate the difference in cell interaction on micro-fibers. The cell activity, proliferation and total protein adsorption on the nano-fibers/nano-fibers with nHAp was significantly higher than on the micro-fibers, although the adsorption per unit area was less on the nano-fibers due to the much higher surface area of nano-fibers. These results suggest that a combination of a micro- and nano-fiber hierarchical scaffold could be more beneficial for tissue engineering applications than the individual scaffolds provided the amount of nano- fibers could be suitably optimized. Copyright © Taylor amp; Francis Group, LLC.
Cite this Research Publication : K. T. Shalumon, Binulal, N. S., Deepthy, M., Dr. Jayakumar Rangasamy, Koyakutty, M., and Shantikumar V Nair, “Preparation, Characterization and Cell Attachment Studies of Electrospun Multi-scale Poly(caprolactone) Fibrous Scaffolds for Tissue Engineering”, Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, vol. 48, pp. 21-30, 2011.