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Publication Type : Journal Article
Publisher : Cent Nerv Syst Agents Med Chem
Source : Cent Nerv Syst Agents Med Chem, Volume 13, Issue 3, p.195-206 (2013)
Url : https://pubmed.ncbi.nlm.nih.gov/24533911/#:~:text=In%20the%20five%20membered%20nitrogen,the%20inhibition%20of%20Monoamine%20oxidase.&text=We%20propose%20that%20the%20selectivity,3%20position%20of%20the%20scaffold.
Keywords : Animals, Humans, Isoenzymes, Molecular Conformation, Monoamine oxidase, Monoamine Oxidase Inhibitors, Pyrazoles, Structure-Activity Relationship
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Year : 2013
Abstract : In the five membered nitrogen containing heterocyclic family, pyrazoline could be recognized as a promising scaffold for the inhibition of Monoamine oxidase. Substitution at 1, 3 and 5-position of the pyrazoline nucleus displayed a significant activity towards MAO in the past 15 years. Our study identified the detailed structure activity relationship, the structural requirement for enzyme interaction and the effect of chirality on the pyrazoline nucleus towards MAO-A and MAO-B. We propose that the selectivity of pyrazoline nucleus towards MAO isoenzyme depends up on the bulkiness of the ring in the 1 and 3 position of the scaffold. The current review revealed that the derivatives of pyrazolines have proven to be versatile pharmacophores for the inhibition of MAO on the basis of existing literatures between (1998-2013).
Cite this Research Publication : Bijo Mathew, Suresh, J., Anbazhagan, S., and Mathew, G. Elizabeth, “Pyrazoline: a promising scaffold for the inhibition of monoamine oxidase.”, Cent Nerv Syst Agents Med Chem, vol. 13, no. 3, pp. 195-206, 2013.