Publication

Abstract : Postpartum hemorrhage is a leading cause of maternal morbidity and mortality worldwide. Tranexamic acid has been shown to reduce blood loss in various surgical settings, but its efficacy in cesarean deliveries remains unclear. To evaluate the efficacy of prophylactic tranexamic acid in reducing blood loss and related complications in patients undergoing cesarean delivery. A randomized, double‐blinded, controlled study was conducted on 200 term pregnant women undergoing cesarean delivery. Participants were randomly allocated to receive either tranexamic acid (n=100) or placebo (n=100). The primary outcome was total blood loss, and secondary outcomes included the incidence of postpartum hemorrhage and the need for additional interventions to control blood loss. The mean total blood loss was significantly lower in the tranexamic acid group (462.89±142.21 mL) compared to the control group (599.26±221.66 mL, P<0.0001). The incidence of postpartum hemorrhage was also significantly lower in the tranexamic acid group (4% vs. 15%, P=0.0081). The tranexamic acid group required fewer additional interventions, including uterotonics (12% vs. 26%, P=0.0118), blood transfusions (7% vs. 21%, P=0.0044) and surgical interventions (6% vs. 14%, P=0.0600). Prophylactic administration of tranexamic acid significantly reduces total blood loss, the incidence of postpartum hemorrhage and the need for additional interventions in patients undergoing cesarean delivery. This intervention may improve maternal outcomes and decrease healthcare costs associated with the management of postpartum hemorrhage.