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A Brief Report on Identification of Splice Variants in an In Vitro 3D Spheroid Model for Differentiated Hepatocellular Carcinoma

Publication Type : Journal Article

Publisher : Elsevier BV

Source : Journal of Clinical and Experimental Hepatology

Url : https://doi.org/10.1016/j.jceh.2025.103151

Keywords : hepatocellular carcinoma, alternative splicing events, transcriptomic sequencing, spheroids

Campus : Faridabad

School : School of Medicine

Year : 2025

Abstract : Hepatocellular carcinoma (HCC) represents the major form of primary liver cancer. Alternative splicing events (ASEs) are critical to generating mRNA splice variants that can dictate cell fate during HCC development. We report different ASEs in a 3D in vitro HCC spheroid model. This short study serves as a template to design functional studies to target different splicing events in different subtypes of hepatocellular carcinoma.

Cite this Research Publication : Shreyas H. Karunakara, Rohit Mehtani, Gopalakrishna Ramaswamy, Vinutha S. Puttamallapa, Prashant M. Vishwanath, Prasanna K. Santhekadur, A Brief Report on Identification of Splice Variants in an In Vitro 3D Spheroid Model for Differentiated Hepatocellular Carcinoma, Journal of Clinical and Experimental Hepatology, Elsevier BV, 2025, https://doi.org/10.1016/j.jceh.2025.103151

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