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Course Detail

Course Name Immunology
Course Code 25MMD511
Program M. Sc. Molecular Medicine(MLM)
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

Basic Concepts in Immunology, Cells and organs of the immune system, Principles of Innate and Adaptive Immunity

Unit 2

Innate Immunity: Recognition and effector mechanisms, Inflammation and its regulation, Complement system.

Unit 3

Adaptive Immunity: Antigen recognition and processing, B and T cell development and activation, Immune memory, Antigen Recognition by B-cell and T-cell Receptors

Unit 4

The Generation of Lymphocyte Antigen Receptors, the generation of diversity in immunoglobulins, T-cell receptor gene rearrangement, Structural variation in immunoglobulin constant regions.

Unit 5

The development and survival of Lymphocytes: Generation of lymphocytes in bone marrow and thymus, the rearrangement of antigen-receptor gene segments controls lymphocyte development, interaction with self-antigens selects some lymphocytes for survival but eliminates others, survival and maturation of lymphocytes in peripheral lymphoid tissues.

Unit 6

T cell-mediated immunity: Production of armed effector T cells, General properties of armed effector T cells, T cell-mediated cytotoxicity, Macrophage activation by armed CD4 TH1 cells.

Unit 7

Immunopathology: Autoimmunity, Allergy and hypersensitivity, Immunodeficiency disorders

Unit 8

Immunotherapy and Vaccines: Monoclonal Antibodies: Production and Applications, Adoptive Cell Therapy and Immunomodulation, Vaccine Development and Immunization Strategies, Currently available vaccines. Immunotherapy in Autoimmune Diseases and Cancer

Unit 9

Immunological Diagnostics: Serological Techniques: ELISA, Western Blotting, Flow Cytometry and

Immunophenotyping, Molecular Diagnostics in Immunology, Point-of-Care Testing in Immunodiagnostics

Objectives and Outcomes

Course Outcomes

CO1

Develop a comprehensive understanding of immunology by encompassing both innate and adaptive immune systems, focusing on fundamental concepts.

CO2

Recognize and understand the crucial cells and organs of the immune system, exploring their roles in immune responses.

CO3

To understand how innate and adaptive immunity work, applying their principles to bolster host defence

CO4

To learn about the mechanisms driving diversity in immunoglobulins and the rearrangement of T-cell receptor genes.

CO5

To learn about the intricate processes guiding the development and survival of lymphocytes, including their formation in the bone marrow and thymus.

CO6

To understand the humoral immune response, including B-cell activation, functions of immunoglobulin types, and how pathogens are destroyed through Fc receptors.

CO7

To understand the mechanisms underlying autoimmune conditions, allergies, hypersensitivity, and immunodeficiency disorders.

CO8

To acquire comprehensive knowledge in advanced immunological diagnostics, cutting-edge applications in immunotherapy and vaccines, insights into immunology’s role in infectious diseases, and an understanding of immune response manipulation.

  • Course Outcome

    • CO1 Knowledge about the microorganisms, basic skills in aseptic/sterilization techniques, antimicrobial agents and microbial diseases. Students will learn the composition of human microbiome and their role in maintaining normal gut function.

    CO2 Will gain knowledge about principles of innate and adaptive immune system, the antigen receptor structure and the mechanisms of antigen recognition by B-cell and T-cells.

    CO3 Gain knowledge about immune signal mechanisms, lymphocyte generation, B-and T-cell receptor gene rearrangements; and lymphocyte development.

    CO4 Will gain knowledge about macrophage and B cell activation by T cells, adaptive Immunity to Infection: immunological memory. Failures of Host Defense Mechanisms, immunodeficiency diseases, acquired immune deficiency syndrome.

    CO5 Gain knowledge about the mechanism of allergic responses, hypersensitivity reactions, autoimmunity and transplantation. The students will also learn about the importance for immunization and manipulation of the immune system to fight infectious disease.

    PO1: Bioscience Knowledge

    PO2: Problem Analysis

    PO3: Design/Development of Solutions

    PO4: Conduct Investigations of complex problems

    PO5: Modern tools usage

    PO6: Bioscientist and Society

    PO7: Environment and Sustainability

    PO8: Ethics

    PO9: Individual & Team work

    PO10: Communication

    PO11: Project management & Finance

    PO12: Lifelong learning

    c

    PO1

    PO2

    PO3

    PO4

    PO5

    PO6

    PO7

    PO8

    PO9

    PO10

    PO11

    PO12

    C O

    CO 1

    3

    1

    1

    1

    –

    –

    –

    –

    –

    –

    –

    1

    CO 2

    3

    1

    1

    –

    –

    –

    –

    –

    –

    –

    –

    1

    CO 3

    3

    1

    1

    –

    –

    –

    		          

    1

    CO 4

    3

    1

    1

    1

    –

    –

    –

    –

    –

    –

    –

    1

    CO 5

    3

    1

    1

    1

    1

    –

    –

    –

    –

    –

    –

    1

    Program Specific Outcomes. (PSO)

    PSO 1 – Biochemical organization and cellular complexity in function

    PSO 2 – Biomolecules in Medicine

    PSO 3 – Molecular basis of disease

    PSO 4 – Molecular technology in diagnosis and therapy

    PSO 5 – Cellular based approaches in diagnosis and therapy

    PSO 6 – Microorganisms in Medicine

    PSO 7 – Nanoscale entities and its significance in Medicine

    PSO 8 – Tissue architecture engineering in Medicine

    PSO 9 – Compounds as drugs and its efficacy

    PSO 10 – Bioinformatics and biological data use

    –

    PSO1

    PSO2

    PSO3

    PSO4

    PSO5

    PSO6

    PSO7

    PSO8

    PSO9

    PSO10

    C O

    CO 1

    3

    1

    2

    –

    –

    3

    –

    –

    1

    –

    CO 2

    3

    –

    1

    –

    –

    –

    –

    –

    –

    –

    CO 3

    3

    1

    1

    –

    1

    –

    –

    –

    –

    –

    CO 4

    3

    –

    1

    –

    –

    –

    –

    –

    –

    –

    CO 5

    3

    –

    3

    –

    2

    –

    –

    –

    –

    –

    Evaluation Pattern

    Evaluation Pattern: 50+50 = 100

    Internal Assessment – 50% 

    Periodical 1 

    Exam 

    20% 

    Periodical 2 

    Exam 

    20% 

    Continuous Assessment 

    Assignment/Test/Quiz

    10% 
     

    50%

    End Semester Examination- 50% 

    Theory Exam 

    50% 

    		  
     

    50%

    Total

    100%

    Text Books / References

    TEXT BOOK:

    1. Janeway’s Immunobiology, Ken Murphy, Paul Travers, Mark Walport, 9th edition.

    REFERENCES:

    1. Kuby Immunology” by Judy Owen, Jenni Punt, and Sharon Stranford , 2018
    2. Clinical Immunology: Principles and Practice” by Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., and Anthony J. Frew, 2018

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