Unit 1
Basic Concepts in Immunology, Cells and organs of the immune system, Principles of Innate and Adaptive Immunity
| Course Name | Immunology |
| Course Code | 25MMD511 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
Basic Concepts in Immunology, Cells and organs of the immune system, Principles of Innate and Adaptive Immunity
Innate Immunity: Recognition and effector mechanisms, Inflammation and its regulation, Complement system.
Adaptive Immunity: Antigen recognition and processing, B and T cell development and activation, Immune memory, Antigen Recognition by B-cell and T-cell Receptors
The Generation of Lymphocyte Antigen Receptors, the generation of diversity in immunoglobulins, T-cell receptor gene rearrangement, Structural variation in immunoglobulin constant regions.
The development and survival of Lymphocytes: Generation of lymphocytes in bone marrow and thymus, the rearrangement of antigen-receptor gene segments controls lymphocyte development, interaction with self-antigens selects some lymphocytes for survival but eliminates others, survival and maturation of lymphocytes in peripheral lymphoid tissues.
T cell-mediated immunity: Production of armed effector T cells, General properties of armed effector T cells, T cell-mediated cytotoxicity, Macrophage activation by armed CD4 TH1 cells.
Immunopathology: Autoimmunity, Allergy and hypersensitivity, Immunodeficiency disorders
Immunotherapy and Vaccines: Monoclonal Antibodies: Production and Applications, Adoptive Cell Therapy and Immunomodulation, Vaccine Development and Immunization Strategies, Currently available vaccines. Immunotherapy in Autoimmune Diseases and Cancer
Immunological Diagnostics: Serological Techniques: ELISA, Western Blotting, Flow Cytometry and
Immunophenotyping, Molecular Diagnostics in Immunology, Point-of-Care Testing in Immunodiagnostics
Course Outcomes
CO1 : Develop a comprehensive understanding of immunology by encompassing both innate and adaptive immune systems, focusing on fundamental concepts.
CO2 :Recognize and understand the crucial cells and organs of the immune system, exploring their roles in immune responses.
CO3 :To understand how innate and adaptive immunity work, applying their principles to bolster host defence
CO4 :To learn about the mechanisms driving diversity in immunoglobulins and the rearrangement of T-cell receptor genes.
CO5 :To learn about the intricate processes guiding the development and survival of lymphocytes, including their formation in the bone marrow and thymus.
CO6 : To understand the humoral immune response, including B-cell activation, functions of immunoglobulin types, and how pathogens are destroyed through Fc receptors.
CO7 :To understand the mechanisms underlying autoimmune conditions, allergies, hypersensitivity, and immunodeficiency disorders.
CO8 : To acquire comprehensive knowledge in advanced immunological diagnostics, cutting-edge applications in immunotherapy and vaccines, insights into immunology’s role in infectious diseases, and an understanding of immune response manipulation.
CO1 Knowledge about the microorganisms, basic skills in aseptic/sterilization techniques, antimicrobial agents and microbial diseases. Students will learn the composition of human microbiome and their role in maintaining normal gut function.
CO2 Will gain knowledge about principles of innate and adaptive immune system, the antigen receptor structure and the mechanisms of antigen recognition by B-cell and T-cells.
CO3 Gain knowledge about immune signal mechanisms, lymphocyte generation, B-and T-cell receptor gene rearrangements; and lymphocyte development.
CO4 Will gain knowledge about macrophage and B cell activation by T cells, adaptive Immunity to Infection: immunological memory. Failures of Host Defense Mechanisms, immunodeficiency diseases, acquired immune deficiency syndrome.
CO5 Gain knowledge about the mechanism of allergic responses, hypersensitivity reactions, autoimmunity and transplantation. The students will also learn about the importance for immunization and manipulation of the immune system to fight infectious disease.
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| c | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| C O | ||||||||||||
| CO 1 | 3 | 1 | 1 | 1 | – | – | – | – | – | – | – | 1 |
| CO 2 | 3 | 1 | 1 | – | – | – | – | – | – | – | – | 1 |
| CO 3 | 3 | 1 | 1 | – | – | – | 1 | |||||
| CO 4 | 3 | 1 | 1 | 1 | – | – | – | – | – | – | – | 1 |
| CO 5 | 3 | 1 | 1 | 1 | 1 | – | – | – | – | – | – | 1 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| – | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 |
| C O | ||||||||||
| CO 1 | 3 | 1 | 2 | – | – | 3 | – | – | 1 | – |
| CO 2 | 3 | – | 1 | – | – | – | – | – | – | – |
| CO 3 | 3 | 1 | 1 | – | 1 | – | – | – | – | – |
| CO 4 | 3 | – | 1 | – | – | – | – | – | – | – |
| CO 5 | 3 | – | 3 | – | 2 | – | – | – | – | – |
Evaluation Pattern: 50+50 = 100
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% | |
TEXT BOOK:
REFERENCES:
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