'Organic Synthesis and Stereochemistry' is a course offered for the B. Tech. programs at the School of Engineering, Amrita Vishwa Vidyapeetham.
Unit 1
Nomenclature of Organic compounds: Polyenes, Alkynes with and without functional groups by IUPAC nomenclature. Aromatic and Heteroaromatic systems - nomenclature of heterocycles having not more than two hetero atoms such as oxygen, sulphur, nitrogen.
Stereochemistry: Tacticity, R/S system of nomenclature of central and axial molecules.
Unit 2
Atropisomerism - isomerism of biphenyls - allenes and spiranes - ansa compounds - Geometrical isomerism, E, Z Isomerism. Asymmetric synthesis.
Conformational Analysis: Optical activity and chirality - Conformational Analysis of cyclic and acyclic system - Conformational effects on reactivity of acyclic systems only.
Unit 3
Asymmetric synthesis: Stereo selective - Stereo specific - Regioselective and Regiospecific reactions. Principle of protection of alcohol, amine, carboxyl and carbonyl groups - Functional group inter conversions - Disconnection approach - Reversal of polarity - reagents in synthesis.
- E. L. Eliel, “Stereochemistry of Carbon Compounds”, McGraw Hill Book Co, (2000).
- Jerry March, “Advanced Organic Chemistry”, 4th edition, John Wiley & Sons, (1992).
- S. Warren, “Designing Organic Synthesis”, Wiley & Sons, (1998).
- Finar I. L, “Organic Chemistry: Stereochemistry and the Chemistry of Natural Products”, 5th edition, ELBS, (2000).
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