'Organic Synthesis and Stereochemistry' is a course offered for the B. Tech. programs at the School of Engineering, Amrita Vishwa Vidyapeetham.
Unit 1
Nomenclature of Organic compounds: Polyenes, Alkynes with and without functional groups by IUPAC nomenclature. Aromatic and Heteroaromatic systems - nomenclature of heterocycles having not more than two hetero atoms such as oxygen, sulphur, nitrogen.
Stereochemistry: Tacticity, R/S system of nomenclature of central and axial molecules.
Unit 2
Atropisomerism - isomerism of biphenyls - allenes and spiranes - ansa compounds - Geometrical isomerism, E, Z Isomerism. Asymmetric synthesis.
Conformational Analysis: Optical activity and chirality - Conformational Analysis of cyclic and acyclic system - Conformational effects on reactivity of acyclic systems only.
Unit 3
Asymmetric synthesis: Stereo selective - Stereo specific - Regioselective and Regiospecific reactions. Principle of protection of alcohol, amine, carboxyl and carbonyl groups - Functional group inter conversions - Disconnection approach - Reversal of polarity - reagents in synthesis.