Qualification: 
Ph.D
binulalns@aims.amrita.edu

Ph. D. in Bioengineering (2013) from Amrita Vishwa Vidyapeetham. Experience as Research Assistant at the Institute of Biomedical Sciences, Taiwan, Taipei, as Visiting Scholar at Mikos Lab, Department of Bioengineering, Rice University, USA, as post-doctoral fellow at ACNSMM, Amrita Vishwa Vidyapeetham, and as Postdoctoral Fellow at the Centre for Bioengineering, Trinity College, Dublin, Ireland. Joined Amrita in 2017, as faculty, to pursue research in the area of bioengineering and regenerative medicine. Has over 20 peer-reviewed research publications and two book chapters to his credit. Research interest is in understanding the fundamentals of immunomodulatory and regenerative properties in adult stem cells and bioengineered matrices, for functional tissue regeneration, and is also focussed on the translational aspects of stem cell products and cell-derived matrices for regenerative medicine.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

S. Pentlavalli, Chambers, P., Binulal N Sathy, O'Doherty, M., Chalanqui, M., Kelly, D. J., Haut-Donahue, T., McCarthy, H. O., and Dunne, N. J., “Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules”, Macromol Biosci, 2017.[Abstract]


In this study, thermoresponsive copolymers that are fully injectable, biocompatible, and biodegradable and are synthesized via graft copolymerization of poly(N-isopropylacrylamide) onto alginate using a free-radical reaction are presented. This new synthesis method does not involve multisteps or associated toxicity issues, and has the potential to reduce scale-up difficulties. Chemical and physical analyses verify the resultant graft copolymer structure. The lower critical solution temperature, which is a characteristic of sol-gel transition, is observed at 32 °C. The degradation properties indicate suitable degradation kinetics for drug delivery and bone tissue engineering applications. The synthesized P(Alg-g-NIPAAm) hydrogel is noncytotoxic with both human osteosarcoma (MG63) cells and porcine bone marrow derived mesenchymal stem cells (pBMSCs). pBMSCs encapsulated in the P(Alg-g-NIPAAm) hydrogel remain viable, show uniform distribution within the injected hydrogel, and undergo osteogenic and chondrogenic differentiation under appropriate culture conditions. Furthermore, for the first time, this work will explore the influence of alginate viscosity on the viscoelastic properties of the resulting copolymer hydrogels, which influences the rate of medical device formation and subsequent drug release. Together the results of this study indicate that the newly synthesized P(Alg-g-NIPAAm) hydrogel has potential to serve as a versatile and improved injectable platform for drug delivery and bone tissue engineering applications.

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