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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Annals of Oncology
Source : Annals of Oncology, Volume 28, Number suppl_5 (2017)
Campus : Kochi
School : School of Medicine
Center : Amrita Hypertrophic Cardiomyopathy Center
Department : Cardiology
Year : 2017
Abstract : Background: Immunoglobulin light chain amyloidosis (AL amyloidosis) is a monoclonal plasma cell proliferative disorder that is characterized by tissue deposits of misfolded insoluble κ and λ light chain derived amyloid fibrils, leading to organ dysfunction. The prognosis of patients depends on the number and severity of organ involvement, especially cardiac involvement. Nearly half of the patients with amyloidosis die within a year of diagnosis. We analysed factors predicting early mortality (within one year) in patients with systemic immunoglobulin light chain cardiac amyloidosis.Methods: Retrospective analysis of patients between January 2007 and January 2016 from our hospital database. In patients with AL cardiac amyloidosis, cardiac involvement was defined as per American society of echocardiography (ASE) criteria. We evaluated the clinical, ECG and ECHO parameters of early relapse (ER) within one year in these cardiac AL amyloidosis patients. Log rank test was done to identify independent predictors of one year all cause mortality.
Cite this Research Publication : S. V., Subramaniam, M., Shanmugam, A., Philip, A., Susan, A., Prabhu, R., Unni, M., Sidharthan, N., Jose, W., V., S. N., Dr. Hisham Ahamed, Mathew, N., and Keechilat, P., “1025PIndependent predictors of one year mortality in patients with primary systemic immunoglobulin light chain cardiac amyloidosis”, Annals of Oncology, vol. 28, 2017.