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Publication Type : Journal Article
Publisher : HeteroCorporation
Source : Journal of Heterocyclic Chemistry, , HeteroCorporation, vol. 53, no. 6, pp. 1778-1782, 2016.
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis, Chemistry
Year : 2016
Abstract : A series of new 4-aryl-4H-chromene-3-carbonitrile derivatives were obtained by one-pot synthesis using substituted benzaldehydes, malononitrile, and substituted phenols. All the synthesized compounds (1a, 1b, 1c, 1d, 1e) were screened in vitro for antioxidant and anticancer activities. Compounds 1c, 1d, 1e showed significant antioxidant activity in nitric oxide free radical scavenging method while compounds 1c and 1e showed significant activity in hydrogen peroxide free radical scavenging method. The other compounds showed significant to moderate activities in both the methods in comparison with ascorbic acid and butylated hydroxytoluene as standards. Compounds 1c, 1d, 1e exhibited good anticancer activity, using Michigan Cancer Foundation-7 (MCF-7) cell line, compared with those of other synthesized compounds. © 2015 HeteroCorporation.
Cite this Research Publication : Na Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies”, Journal of Heterocyclic Chemistry, vol. 53, no. 6, pp. 1778-1782, 2016.