Publication Type : Journal Article
Thematic Areas : Biotech
Publisher : Elsevier
Source : Tetrahedron letters, Elsevier, Volume 40, Number 4, p.767–770 (1999)
Url : http://www.sciencedirect.com/science/article/pii/S0040403998024071
Campus : Amritapuri
School : School of Biotechnology
Center : Biotechnology, Phytochemistry Labs
Department : biotechnology
Year : 1999
Abstract : Low valent titanium mediated cleavage of Npropargyl bonds offers a facile, mild, and high yielding method for the deprotection of amines under neutral conditions. The methodology could be used for the chemoselective removal of propargyl groups from amines in preference to the allyl/benzyl counterparts and can be performed chemoselectively in the presence of methoxy, methylenedioxy, and chloro functionalities.
Cite this Research Publication : S. Rele, Talukdar, S., and Banerji, A., “A facile radical induced selective removal of N-propargyl protecting groups using low valent titanium reagents”, Tetrahedron letters, vol. 40, pp. 767–770, 1999.