Publication Type : Journal Article
Publisher : IJCB
Source : International. Journal for Computational Biology (IJCB) 2019, 8 (1).
Url : https://www.researchgate.net/profile/Sonal-Gupta-18/publication/340645152_A_Molecular_Docking_and_Pharmacokinetic_Prediction_of_Thiazolidine-2_4-dione_Derivatives_Toward_Novel_Therapeutic_Targets_for_Type-2_Diabetes_Mellitus/links/5e969c0a4585150839de71ff/A-Molecular-Docking-and-Pharmacokinetic-Prediction-of-Thiazolidine-2-4-dione-Derivatives-Toward-Novel-Therapeutic-Targets-for-Type-2-Diabetes-Mellitus.pdf
Campus : Amritapuri
School : School of Biotechnology
Department : Chemistry
Year : 2019
Abstract : Type 2 diabetes mellitus (T2DM) is a leading endocrine disorder that affects
millions of people worldwide. It is characterized by hyperglycemia and high
insulin resistance. The commonly prescribed oral therapeutic for insulin
resistance in T2DM is Thiazolidine-2, 4-diones (TZDs). TZDs are a class of
oral hypoglycemic agents that act on Peroxisome proliferator activating
receptor-γ (PPAR-γ) receptors and are mainly expressed in the adipose tissues.
In this work, we derive novel classes of TZDs and predict the nature of
Keyword: structural affinity using docking studies against the PPAR-γ
Cite this Research Publication : Tiwari, P.; Suravajhala, R.; Gupta, S.; Chaturvedi, P.; Mathur, S. K.; Solanki, P. S.; Malik,B. A Molecular Docking and Pharmacokinetic Prediction of Thiazolidine-2, 4-Dione Derivatives: Toward Novel Therapeutic Targets for Type-2 Diabetes Mellitus. International. Journal for Computational Biology (IJCB) 2019, 8 (1).