Publication Type : Journal Article
Thematic Areas : Medical Sciences, Nanosciences and Molecular Medicine
Publisher : J Hosp Infect
Source : Journal of Hospital Infection, 2019
Url : https://doi.org/10.1016/j.jhin.2018.09.008
Keywords : Ultraviolet-C, Octenidine dihydrochloride, Candida auris, Colonization, Disinfection
Campus : Amritapuri, Kochi
School : Center for Nanosciences, School of Biotechnology, School of Medicine
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Biotechnology, Nanosciences
Department : Nanosciences and Molecular Medicine, Microbiology
Year : 2019
Abstract : Outbreaks due to multidrug-resistant Candida auris have emerged as a large threat to modern medicine. Since skin colonization and environmental contamination have been identified as a precursor for outbreaks, we evaluated the antifungal activity of ultraviolet-C light using mercury vapour lamp with a peak emission of 254 ± 2 nm and octenidine dihydrochloride against C. auris clinical isolates. Octenidine dihydrochloride was found effective at significantly lower concentrations (0.00005-0.0004%) than those currently used in the clinical setting (0.05-0.1%). Scanning electron microscopy images show destruction of the organism within 6 h of exposure to 0.0005% octenidine dihydrochloride. Ultraviolet-C light could kill all C. auris with 15 min exposure.
Cite this Research Publication : P.Ponnachan, V.Vinod, U.Pullanhi, P.Varma, S.Singh, R.Biswas, A.Kumar "Antifungal activity of octenidine dihydrochloride and ultraviolet-C light against multidrug-resistant Candida auris", Journal of Hospital Infection, 2019