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Biosynthesis, characterization and evaluation of silver nanoparticles of alternanthera sessilis (linn.) and its ethanolic extract in high fat diet induced dementia model

Publication Type : Journal Article

Publisher : International Journal of Phamraceutical Sciences Review and Research.

Source : International Journal of Phamraceutical Sciences Review and Research., Volume 42, Issue 2, p.160-165 (2017)

Campus : Kochi

School : School of Pharmacy

Department : Pharmacology

Year : 2017

Abstract : The present work focuses the use of the aqueous extract of Alternanthera sessilis Linn. (Amaranthaceae) in producing silver nanoparticles (AgNPs) from silver nitrate aqueous. Phytochemical analysis of the extract revealed the presence of alkaloid, tannins, ascorbic acid, carbohydrates and proteins and they serve as effective reducing and capping agents for converting silver nitrate into nanoparticles. The synthesized silver nanoparticles (AgNPs) were also tested for proteins and ascorbic acid. Its pH was also determined (5.63). The AgNPs obtained was characterized by UV–vis spectroscopy, FT-IR spectroscopy, SEM, Zeta sizer and TG–DSC. SEM images which revealed the presence of various shapes and sizes. FT-IR spectrum showed the AgNPs having a coating of proteins indicating a dual role of bio-molecules responsible for capping and efficient stabilization of the silver nanoparticles. Presence of impurities and melting point profile were screened by TG–DSC analyzer. AgNPs were synthesized from the silver nitrate through the reducing power of ascorbic acid present in A. sessilis leaves. In this study, we also investigated antimicrobial and antioxidant activity of green synthesized AgNPs. The antimicrobial activity is investigated by

Cite this Research Publication : S. P. Ittiyavirah and Jahanara Hameed, “Biosynthesis, characterization and evaluation of silver nanoparticles of alternanthera sessilis (linn.) and its ethanolic extract in high fat diet induced dementia model”, International Journal of Phamraceutical Sciences Review and Research., vol. 42, no. 2, pp. 160-165, 2017.

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