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Candida haemulonii species complex: an emerging species in India and its genetic diversity assessed with multilocus sequence and amplified fragment-length polymorphism analyses.

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Emerg Microbes Infect

Source : Emerging Microbes & Infections Volume 5, 2016

Url : http://dx.doi.org/10.1038/emi.2016.49

Keywords : Amplified Fragment Length Polymorphism Analysis, Candida, Candidiasis, Communicable Diseases, Emerging, Genetic Variation, Humans, India, Multilocus Sequence Typing, phylogeny

Campus : Kochi

School : School of Medicine

Department : Microbiology

Year : 2016

Abstract : The epidemiology of Candida species-associated invasive fungal infections is evolving, and many uncommon Candida species have recently emerged as etiologic agents of bloodstream and other invasive infections. This emergence is attributable to the use of antifungal drugs, such as azoles, for prophylaxis and echinocandins among high-risk populations. Notably, these species exhibit decreased in vitro susceptibility to the antifungals used for therapy.1 In the last few years, clinical treatment failures for Candida haemulonii infections associated with resistance to amphotericin B (AMB) and reduced susceptibility to azoles and echinocandins have been reported.2, 3, 4 Members of the Candida haemulonii species complex are uncommon yeasts that cause bloodstream and deep-seated infections, and consist of two genotypically distinguishable species, that is, C. haemulonii and C. duobushaemulonii, and a variety, C. haemulonii var. vulnera.2 These species and other relatives of C. haemulonii, that is, Candida auris and Candida pseudohaemulonii, cannot be differentiated by the commercial yeast identification methods used in microbiology laboratories; thus, the true distributions of C. haemulonii and sibling species remain unknown.

Cite this Research Publication : Anil Kumar, Anupam Prakash, Ashutosh Singh, Harish Kumar, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary "Candida haemulonii species complex: an emerging species in India and its genetic diversity assessed with multilocus sequence and amplified fragment-length polymorphism analyses", Emerging Microbes & Infections Volume 5, 2016

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