Publication Type : Journal Article
Publisher : Epigenetics
Source : Epigenetics, Volume 5, Number 3, p.241-248 (2010)
Keywords : animal experiment, article, comparative study, controlled study, CpG island, DNA methylation, female, fragile X mental retardation protein, gender, gene repression, gene sequence, male, mouse, Mus musculus, nonhuman, nucleotide sequence, transgenic mouse
Campus : Amritapuri
School : School of Engineering
Department : Electrical and Electronics, Electronics and Communication
Year : 2010
Abstract : Methylation of CpG sequences in and around CGG triplet repeats in FMR1 gene has strong correlation with manifestation of the fragile X syndrome in human patients. In contrast, we have observed a lack of correlation between repeat instability and DNA methylation in three different transgenic mouse models harboring unstable CGG repeats. Further we have demonstrated that the endogenous copy of mouse Fmr1 gene remains unmethylated both in males and females. These results imply that methylation and repeat instability are independent events and raise the possibility that methylation could also result in repression of FMR1 transcription in the absence of repeat expansion. © 2010 Landes Bioscience.
Cite this Research Publication : M. Pa Alam, Datta, Sb, Majumdar, Sc, Mehta, A. Kad, Baskaran, Sad, Gulati, Nb, and Brahmachari, Va, “Comparative analysis of DNA methylation in transgenic mice with unstable CGG repeats from FMR1 gene”, Epigenetics, vol. 5, pp. 241-248, 2010.