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Abstract : The objective of the proposed study was an a of adverse effects of anti epileptic drugs through the patient medication interview and a of Cognitive impairment. Study was carried out in 100 bedded Private neuro-hospital, Erode. All types of epileptic patients (ambulatory patients) and 100 healthy volunteers were included in this study to compare the cognitive level with the patients. Epileptic with any other co-morbid condition like head injury, stroke, trauma, congenital malfunctioning, mental sub normality, children (below 13yrs) and tumor were excluded from the study. The total number of epileptic patients (ambulatory patients) were interviewed in the study site during the study period were found to be 114. Gender distribution of the study population was given, which indicates a predominant male (58%) population. The average age of the overall study population was found to be 26.74±11.95 (13 to 65) years. The result shows that p with Complex partial seizure (24%) were extremely diagnosed at the study site. Phenytoin (46%) is majorly prescribed antiepileptic drug followed by Sodium valproate (36%), carbamazepine (32%), etc. Drowsiness is the commonly reported adverse effect (37%) followed by headache (15.57%), weight gain, alopecia, anorexia, etc. Mini mental status (MMSE scale) analysis revealed that half of the patient was 19 to 10scored (81%) followed by 20 to 22 scored (17%) etc. This indicates patient with epilepsy and/or anti epileptic therapy affect cognition. So the pharmacist can play a pivotal role in the management of epilepsy by monitoring the adverse effects, cognitive level by providing the guidelines to educate and motivate the patients regularly.