Publication Type : Journal Article
Publisher : Der Pharma Chemica
Source : Der Pharma Chemica, vol. 4, pp. 644-649, 2012
Keywords : accuracy, analytical parameters, article, asenapine, asenapt, Beers law, calibration, concentration (parameters), controlled study, drug absorption, drug determination, drug dosage form, drug solubility, drug solution, drug structure, limit of detection, limit of quantitation, linearity, methanol, Reliability, robustness, ruggedness, tablet, ultraviolet spectrophotometry, unclassified drug, validation study
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Year : 2012
Abstract : A simple, accurate, precise and sensitive UV spectrophotometric method was developed for the determination of Asenapine maleate in bulk and pharmaceutical dosage form. The solvent used is methanol and the wavelength corresponding to maximum absorbance of the drug was found at 270nm. Beers law was observed in the concentration range of 10-60μg/ml with correlation coefficent 0.9997. The linear regression equation obtained by least square regression method were y=0.0132X-0.0016, where y is the absorbance and x is the concentration of the pure drug solution. The method was validated for several parameters like accuracy, precision as per ICH guidelines. The values of relative standard deviation and % recovery were found to be satisfactory, indicating that the proposed method is precise and accurate and hence can be used for the routine analysis of Asenapine maleate in bulk and pharmaceutical formulation.
Cite this Research Publication : O. A. Halima, Dr. Aneesh T. P., Ghosh, R., and Thomas, N. R., “Development and validation of UV spectrophotometric method for the estimation of asenapine maleate in bulk and pharmaceutical formulation”, Der Pharma Chemica, vol. 4, pp. 644-649, 2012