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Publication Type : Journal Article
Thematic Areas : Biotech
Publisher : Electrochimica Acta
Source : Electrochimica Acta, Volume 55, Number 5, p.1612 - 1618 (2010)
Keywords : Working model
Campus : Coimbatore
School : School of Engineering
Center : Biosensor Research Lab, Biotechnology
Department : biotechnology, Sciences
Year : 2010
Abstract : Copper oxide (CuO)/copper oxalate (CuOx) modified non-enzymatic electrochemical sensor for the detection of glucose in alkaline medium was fabricated by electrochemical anodisation of copper electrodes in potassium oxalate solution. Morphology of the modified copper electrode was studied by Scanning Electron Microscopy (SEM) and its electrochemical behaviour by Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS). The formation of CuOx on the copper electrode was confirmed by the Infra-red Reflection Absorption Spectrum (IRRAS). The modified electrodes were found to be microporous and rough. Linear Sweep Voltammetry (LSV) and amperometry were adopted to investigate the direct electrocatalytic oxidation of glucose on CuO/CuOx modified electrode in alkaline medium which showed excellent catalytic activity. The best performance of the sensor was obtained at 0.7nbsp;V and in 0.1nbsp;M sodium hydroxide (NaOH). At this optimum potential, the sensor was highly selective to glucose in the presence of ascorbic acid (AA) and uric acid (UA) which are common interfering species in biological fluids. The sensitivity was found to be very high (1890nbsp;μAnbsp;mM−1nbsp;cm−2) with excellent linearity (Rnbsp;=nbsp;0.9999) up to 15nbsp;mM having a low detection limit of 0.05nbsp;μM (S/Nnbsp;=nbsp;3). The modified electrode was tested for glucose level in blood serum. Based on the optimised conditions, a working model of the sensor was made and successfully tested for glucose.
Cite this Research Publication : Dr. Satheesh Babu T. G. and T. Ramachandran, “Development of Highly Sensitive Non-Enzymatic Sensor for the Selective Determination of Glucose and Fabrication of a Working Model”, Electrochimica Acta, vol. 55, pp. 1612 - 1618, 2010.