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Effect of 5-fluorouracil treatment on IL-2R gene expression in gastric carcinoma patients

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Oncology Reports

Source : Oncology Reports, Volume 3, Number 1, p.223-225 (1996)

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Keywords : adult, aged, article, clinical article, controlled study, fluorouracil, gene expression, human, interleukin 2 receptor, intravenous drug administration, messenger RNA, priority journal, stomach carcinoma

Campus : Kochi

School : School of Medicine

Year : 1996

Abstract : Interleukin-2R gene expression was evaluated in peripheral blood T lymphocytes of patients with gastric carcinoma and normal healthy controls. The presence of mRNA for IL-2Rα evaluated by Northern blot analysis revealed that unstimulated T cells expressed lower levels of IL-2R mRNA than PHA stimulated T cells. Expression of both IL-2Rα transcripts (3.5 and 1.5 kb) were either not detectable or only weakly detectable on T lymphocytes from patients even after mitogenic stimulation. In contrast, a significant rise in the expression of both IL-2Rα transcripts was observed on T cells from normal controls followed by mitogenic challenge. Enhanced expression of both IL-2R transcripts was also detected in a follow-up study of the patients, conducted one month following initial trial of chemotherapy with 5-fluorouracil (5 Fu). Patients post chemotherapy were better responders of PHA stimulation as reflected by enhanced IL-2R gene expression following mitogenic challenge.

Cite this Research Publication : Dr. Damodaran Vasudevan, “Effect of 5-fluorouracil treatment on IL-2R gene expression in gastric carcinoma patients”, Oncology Reports, vol. 3, pp. 223-225, 1996.

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