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Fabrication of Alginate/NanoTiO2 Needle Composite Scaffolds for Tissue Engineering Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 83, Number 2, p.858-864 (2011)

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Keywords : Alginate, Alginate scaffolds, Biocompatible Materials, Biodegradable polymers, biomineralization, Biopolymers, Cell attachments, Composite scaffolds, Cytocompatibility, degradation, FTIR, MTT assays, Nano ceramics, Nano-TiO, Nanocomposites, Naturally occurring, Needles, Osteogenesis, Polymeric scaffold, Polymers, Pore wall, Scaffolds, SEM, Tissue, tissue engineering, Tissue engineering applications, Tissue regeneration, XRD

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : Alginate is a naturally occurring polymer that has been widely accepted as biodegradable and biocompatible material. Incorporation of nanoceramic will improve the capability of polymeric scaffold for tissue regeneration. Hence, in this study we fabricated a nanocomposite scaffold using alginate with nanoTiO2 needles by lyophilization technique. The prepared nanocomposite scaffold was characterized using SEM, XRD, FTIR and TGA. In addition, swelling, degradation and biomineralization capability of the scaffold were also evaluated. The developed nanocomposite scaffolds showed well controlled swelling and degradation when compared to the control alginate scaffold. Cytocompatibility was assessed using MTT assay and cell attachment studies. Results indicated no sign of toxicity and cells were found to be attached to the pore walls offered by the scaffolds. These results suggested that the developed nanocomposite scaffold possess the prerequisites for tissue engineering application. Hence, alginate/nanoTiO2 composite scaffold can be used as a better option for tissue regeneration. © 2010 Elsevier Ltd. All rights reserved.

Cite this Research Publication : V. V. D. Rani, Ramachandran, R., Chennazhi, K. P., Tamura, H., Shantikumar V Nair, and Dr. Jayakumar Rangasamy, “Fabrication of Alginate/NanoTiO2 Needle Composite Scaffolds for Tissue Engineering Applications”, Carbohydrate Polymers, vol. 83, pp. 858-864, 2011.

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