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Publication Type : Journal Article
Publisher : Carbohydrate Polymers
Source : Carbohydrate Polymers, Volume 80, Number 2, p.443-449 (2010)
Keywords : 5-fluorouracil, AFM, Anticancer drug, Breast cancer cells, Breast cancer treatment, Cancer cells, Carboxymethyl chitosan, Cell culture, Cells, chitin, chitosan, Controlled drug delivery, drug carrier, Drug loaded nanoparticle, Fluorescent microscopy, Folate receptor, Folic acids, In-vitro, Manganese, Manganese compounds, Metabolic activity, Nanoparticles, Non-toxicity, Optical waveguides, Organic acids, quantum dot, SEM, Semiconductor quantum dots, Size ranges, Stable luminescence, Targeted drug delivery, UV- and, zinc, zinc sulfide, Zinc sulphide, ZnS:Mn nanoparticles
Campus : Kochi
School : Center for Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2010
Abstract : We developed a novel folic acid (FA) conjugated carboxymethyl chitosan coordinated to manganese doped zinc sulphide quantum dot (FA-CMC-ZnS:Mn) nanoparticles. The system can be used for targeting, controlled drug delivery and also imaging of cancer cells. The prepared nanoparticles were characterized using SEM, AFM, FT-IR, UV and DLS studies. The size range of 5-FU encapsulated FA-CMC-ZnS:Mn nanoparticles were from 130 to 150 nm. The anticancer drug selected in this study was 5-Fluorouracil which can be used for the breast cancer treatment. The nontoxicity of FA-CMC-ZnS:Mn nanoparticles were studied using L929 cells. Breast cancer cell line MCF-7 was used to study the imaging, specific targeting and cytotoxicity of the drug loaded nanoparticles. The in vitro imaging of cancer cells with the nanoparticles studied using fluorescent microscopy. The bright and stable luminescence of quantum dots can be used to image the drug carrier in cancer cells without affecting their metabolic activity and morphology. © 2009 Elsevier Ltd. All rights reserved.
Cite this Research Publication : M. Ea Mathew, Mohan, J. Ca, Manzoor, Ka, Nair, S. Va, Tamura, Hb, and Jayakumar, Ra, “Folate conjugated carboxymethyl chitosan-manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells”, Carbohydrate Polymers, vol. 80, pp. 443-449, 2010.