Publication Type : Book Chapter
Publisher : Springer Nature Singapore
Source : Hypoxia in Cancer: Significance and Impact on Cancer Therapy
Url : https://doi.org/10.1007/978-981-99-0313-9_11
Campus : Kochi
School : School of Medicine
Year : 2023
Abstract : Hypoxia and the hypoxia-inducible factors (HIFs) regulate various characteristic features of cancers such as genetic instability, dedifferentiation, metabolic alterations, neovascularization, metastasis, and drug resistance. Therefore, targeting the hypoxic phenotype is a good approach to eradicate malignant cells. Theoretically, HIF inhibition could overcome the resistance to chemotherapy. So, HIF inhibitors are useful targets in the treatment of cancer. Researchers are trying to get specific HIF-1 inhibitors for successful clinical exploitation. HIFs mediate the response, primarily by acting as transcription factors, which are also good targets for treatment.
Cite this Research Publication : D. M. Vasudevan, Sukhes Mukherjee, Role of Hypoxia in Cancer Therapy: Introduction, in Hypoxia in Cancer: Significance and Impact on Cancer Therapy, Springer Nature Singapore, 2023, https://doi.org/10.1007/978-981-99-0313-9_11