Publication Type : Journal Article
Publisher : Thieme
Source : Synlett, 2011
Url : https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0031-1289889
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2011
Abstract : Aldol reactions of 3-aryl-1-alkyl dihydrothiouracils were investigated with respect to the orientation of the exocyclic group at N1, electronic effects of the aryl substituent at N3 and the steric demands of the electrophile. The reactions highlight the preference for formation of the anti aldol diastereomer with increasing steric constraints of the reactants.
Cite this Research Publication : Varun Kumar, Gopal L. Khatik and Vipin A. Nair, "Sterically controlled stereoregulations in aldol reactions of 3-aryl-1-alkyl dihydrothiouracils", Synlett, 2011, 22, 2997-3001.