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Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus.

Publication Type : Journal Article

Publisher : Indian J Dent Res

Source : Indian J Dent Res, Volume 27, Issue 3, p.230-5 (2016)

Url : http://www.ncbi.nlm.nih.gov/pubmed/27411649

Keywords : Absorption, Physiological, Administration, Topical, adult, Chromatography, High Pressure Liquid, female, Glucocorticoids, Humans, Lichen Planus, Oral, male, middle aged, Pain Measurement, Pilot Projects, treatment outcome, triamcinolone acetonide

Campus : Kochi

School : School of Dentistry

Department : Oral Medicine and Radiology

Year : 2016

Abstract : CONTEXT: /bTopical corticosteroids are the treatment of choice for oral lichen planus (OLP) due to its potential anti-inflammatory effect. However, chronic nature of OLP often requires long-term and frequent applications, exposing patients to local and systemic side effects./ppbAIM: /bTo detect the systemic absorption of 0.1% triamcinolone acetonide (TAC) through the oral mucosa of patients with OLP./ppbSUBJECTS AND METHODS: /bThis was a pilot pharmacokinetic study carried out in the Department of Oral Medicine and Radiology in collaboration with the Department of Toxicology, over 10 months. A total of twenty patients with OLP were included and advised to apply 0.1% TAC 3 times/day for 2 weeks and 2 times/day for next 2 weeks. Blood samples were obtained on the first and second visits and analyzed for triamcinolone using High pressure liquid chromatography (HPLC)./ppbSTATISTICAL ANALYSIS USED: /bPaired t-test was done to compare visual analog scale (VAS) score for burning sensation at the first and second visits, statistically significant if P 0.05. The baseline demographic data were analyzed using descriptive statistics./ppbRESULTS: /bPaired t-test was done to compare VAS score for burning sensation at the first and second visits, which turned to being statistically significant (P = 0.001). Although HPLC is an established method for the detection of TAC, none of the study populations showed evidence of steroid (TAC) in the blood sample during 4 weeks of treatment duration./ppbCONCLUSIONS: /b0.1% triamcinolone is a relatively safe drug to be used with no systemic absorption in the standard dose regimen for oral lichen palnus

Cite this Research Publication : A. Aruna Ramadas, Jose, R., Arathy, S. L., Kurup, S., Chandy, M. Lazar, and Kumar, S. P., “Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus.”, Indian J Dent Res, vol. 27, no. 3, pp. 230-5, 2016.

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