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Publication Type : Journal Article
Publisher : Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII,
Source : Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, International Society for Optics and Photonics (2007)
Keywords : Elasticity, soft tissue, Storage modulus, tissue stiffness, Ultrasound Assisted Optical elastography
Campus : Amritapuri
School : School of Engineering
Department : Electronics and Communication
Year : 2007
Abstract : In ultrasound assisted optical elastography (UAOE) the amplitude of vibration inside the object introduced by an ultrasound (US) beam is read out by a coherent light beam. The measurement is the depth of modulation in the intensity autocorrelation of light that intercepted the insonified region and detected at the boundary. It is observed that the measured depth of modulation is owing to refractive index modulation and scattering coefficient modulation, in addition to the tissue-particle vibration. Since elasticity is measured from the amplitude of vibration it is essential to characterize and separate the contribution to the modulation from refractive index and scattering coefficient modulations. In this work we report the contribution of the scattering coefficient modulation in the insonified region to the measured modulation in the autocorrelation. We found through simulation studies that the contribution from scattering coefficient is small compared to the vibration. In addition, this contribution becomes smaller as the stiffness in the region increases. We also provide a means of quantifying this contribution so that the effect of vibration amplitude can be separated from the overall measured modulation depth.
Cite this Research Publication : R. Sreekumari Bharat Chandran, Ushadevi Amma C., R. Mohan Vasu, and Ajay K. Sood, “Ultrasound assisted optical elastography for measurement of tissue stiffness: contribution to the measurement from scattering coefficient variation”, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 2007.