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WR-1065 as a chemoprotector in Adriamycin chemotherapy

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Cancer Letters

Source : Cancer Letters, Volume 81, Number 2, p.171-175 (1994)

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Keywords : 2 (3 aminopropylamino)ethanethiol, animal, animal experiment, animal model, antineoplastic agent, article, cancer chemotherapy, controlled study, DNA damage, doxorubicin, drug toxicity, ehrlich ascites tumor, free radical, heart injury, Inbred BALB C, lipid peroxidation, liver injury, Lung injury, Mercaptoethylamines, Mice, mouse, nonhuman, priority journal, protective agent

Campus : Kochi

School : School of Medicine

Year : 1994

Abstract : The protective effect of WR-1065 against the side effects of Adriamycin was studied in tumor bearing mice. It has been noticed that WR-1065 pretreatment improved the Adriamycin toxicities such as increased enzyme levels, pathological lesions in lung, liver and heart and increased rate of lipid peroxidation, without reducing its anticancer property.

Cite this Research Publication : Dr. Damodaran Vasudevan, Bhanumathi, P., and Saleesh, E. D., “WR-1065 as a chemoprotector in Adriamycin chemotherapy”, Cancer Letters, vol. 81, pp. 171-175, 1994.

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