• Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for berberine are phellodendron and coptis. Similar isoquinoline alkaloids (jateorrhizine, coptisine, palmatine, and columbamine) in these two herbs also have a yellowish color.

    synthesis-of-intermediate-analogues-for-biologically-active-molecules
  • Prognosis and diagnosis are important aspects of any state-of-the-art aerospace application. Machine condition based monitoring and maintenance can help enhance the system performance and prevent system failures. It also helps reduce maintenance costs. Line replaceable units (LRU) are the basic components in any aerospace system that can be easily replaced during maintenance.

    scalable-fault-models-for-prognosis-and-diagnosis-of-generators-in-aircraft-electrical-systems
  • Several projects are focused on the development of nanomedicines for application in cancer therapeutics, drug delivery for infectious diseases and also for regeneration of tissues using nanostructured scaffolds. Some of the tissues studied are bone, cartilage, cardiac tissue, vascular tissue and liver tissue. A wide range of natural polymeric nanostructured materials and bioceramics are being investigated for such applications.

    nanomedicine-and-tissue-engineering
  • In 2011, Amrita Center for Nanosciences and Molecular Medicine was chosen for a TUE in Tissue Engineering and Medical Bio Nanotechnology by the Nanomission of the Government of India. The TUE focuses on translational biomedical products where nanomaterials play an enabling role. This includes nanomedicines using organic non-toxic encapsulants, surface modified products, multifunctional diagnostic nanoparticles, and tissue engineered implants.

    thematic-unit-of-excellence-tue-on-tissue-engineering-and-medical-bio-nanotechnology
  • Bronze alloys (Cu-Sn) are widely used as bearing materials in aircrafts, automobiles, machine tools, and general engineering applications such as dies for plastic injection molding. However, they are in use for a long time in wrought and cast forms, without enhancing their strength and hardness.

    development-of-bronze-alloys-and-comparison-of-their-mechanical-and-wear-properties
  • The project proposes to extend the nano-toxicological investigations of developed multifunctional NPs. It aims to extend the previous study to develop new theragnostic nanomedicines.

    nano-toxicology-and-nano-medicine-phase-ii
  • This study involves the development of a nutraceutical product using coconut water as the main ingredient by incorporating some of the traditionally used natural antioxidants, such as, extracts from plants like Trichopus, Sp.Carrot, Grape seed. etc, without affecting stability. The research involves characterization of taste, anti-oxidant potential and stability of a variety of different formulations.

    nutraceutical-preparation-using-coconut-water
  • Induced pluripotent stem cells (iPSc) are somatic cells that have been reprogrammed to a pluripotent state. These iPSc have similar characteristics to embryonic stem cells and hold great promise in various aspects of research. The aim of this study is to develop patient specific stem cells to understand disease mechanism and identify drugs that will prevent malignant transformation.

    generation-of-induced-pluripotent-stem-ips-cells-from-genetically-altered-somatic-cells
  • This project deals with nano-toxicological evaluation of silica nano-particle based agricultural products such as neutraceuticals and pesticides.

    toxicology
  • This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture. The main goals include understanding cerebellum granule neuron’s role in signal propagation and information processing in a central neuronal network. The other major focus will be on the analysis of cerebellar microcircuits for designing electronic neural processors.

    bio-inspired-processor-design-for-cognitive-functions-via-detailed-computational-modeling-of-cerebellar-granular-layer
  • As part of the India 4 EU program, Dr. Zeena S. Pillai, Department of Chemistry, Amrita School of Arts and Sciences, had the opportunity to work at the University of Bologna in Italy for two months from June 2011-July 2011. The collaborative research was on Photophysical and Co-ordination Properties of Cyclam Core Dendrimers. They selected dansylated dendrimers with cyclam core and studied its complexation properties with lanthanides.

    photophysical-and-co-ordination-properties-of-cyclam-core-dendrimers
  • This project is an observational, prospective and laboratory based retrospective multi-centre, national study of invasive disease caused by S.Pneumoniae or H.influenzae or N. meningitis in children < 5 years of age. Two aspects are covered: one, a study of disease burden indicators and, two, study of the organism characteristics covering a well defined population in a specific geographical area.

    population-survey-of-invasive-diseases-in-india-caused-by-s-pneumoniae-or-h-influenzae-or-n-meningitis-in-children-below-5-years-of-age
  • Visual cryptography is a perfectly secure way to protect secrets and is characterized by its decryption method. This project is to develop new visual cryptographic scheme satisfying certain conditions. In this project, a secret image is split into a set of shares, so that some authorized shares can have access to the secret, where as other unauthorized shares cannot leak out any secret information.

    development-of-visual-cryptographic-schemes
  • The project proposes to enhance the technology used, looks to provide a more comprehensive system, and expand the knowledge of landslides and their detection. This project deals with enhancing and deploying integrated landslide monitoring and detection systems using the emerging wireless sensor network technology to predict rainfall induced landslides in landslide-prone areas of India.

    monitoring-and-detection-of-rainfall-induced-landslide-using-an-integrated-wireless-network-system
  • In the conventional power supply scenario, the electric power feeders in different areas are manually switched off when the demand goes above the scheduled supply. This causes immense revenue loss to the utilities besides discomfort to the consumers. Grid integration of intermittent and uncontrolled generation schemes like wind farms makes the situation worse with conventional power system control.
      

    energy-management-on-smart-grid-using-embedded-systems
  • The primary objective of the project is to develop soft, compliant, lead-free, low-melting-temperature solder materials by electrodeposition. These materials are candidates to replace lead-tin alloys in flip-chip technology for microelectronic packaging.

    Specifically, the goals are:

    electrodeposition-of-lead-free-solder-materials-for-microelectronic-packaging
  • The Online Labs is an educational initiative pioneered by AmritaCREATE, the Amrita Center for Research in Analytics, Technologies & Education at Amrita Vishwa Vidyapeetham in partnership with CDAC, Mumbai; under a research grant from the Department of Information Technology, Government of India.  

    online-labs-olabs-for-school-lab-experiments-interactive-simulations
  • This project is to create an impact on the level of independence of people with disabilities. To ease the lives of those among us who are unfortunate enough to have lost the ability to move their limbs due to stroke, (SCI - Spinal Cord Injury), old age and other disabilities (SSEP Group), Mudra is the perfect solution. Conventional control mechanism, joy stick, is not suitable for SSEP group of people as the joy stick requires the user to hold it and exert some force.

    mudra-hand-gesture-based-wheelchair-navigation
  • This project proposes to develop novel natural biopolymeric composite hydrogel bandages based alginate, chitin and chitosan with antibacterial Herb Hemigraphis Ulternata/ZnO nanoparticles. This three-year project will involve preparation and characterization of nanostructured hydrogel bandages followed by in-vitro protein adsorption, antibacterial, blood clotting, cell attachment and proliferation.

    development-of-natural-biopolymeric-hydrogel-bandages-with-nanozno-nanosuspensions-of-herb-hemigraphis-ulternata-for-wound-dressing
  • Speaker recognition systems are useful for deriving intelligence information by tracking telephone conversations of people who are perceived to be a threat to the national security. Rules prohibit security agencies from eavesdropping on telephone conversations of private citizens. However, it may be necessary to eavesdrop on people with questionable national integrity.

    development-of-text-language-independent-speaker-recognition-system
  • The project on novel target-specific multiplexed nanophytomedicines for cancer therapy, funded by ICMR, focuses on the importance of dietary phytochemicals in sensitizing breast cancers that are resistant to chemodrugs such as Paclitaxel in clinical use.

    novel-target-specific-multiplexed-nano-phytomedicines-for-cancer-therapy
  • This project aims to develop a synergistic collaboration between an active nanomedicine team from the Faculty of Pharmacy, University of Porto, Portugal and a strong nano medicine group at the Amrita Center for Nanosciences, AIMS, Kochi, India. The broad area of this targeted nanomedicine research is lung cancer, which is a very serious disease in both the collaborating countries.

    novel-targeted-chitosan-based-therapeutic-polymeric-nanomedicines-for-lung-cancer-applications
  • NFES is a nationwide, web-based, searchable electronic repository that acquires, maintains, and provides information about the research and publications of the faculty of educational institutions under MHRD.

    national-faculty-expertise-system
  • This three-year project involves preparation of nanostructured scaffolds, plasma treatment of the scaffolds, followed by in-vitro protein adsorption, cell attachment and proliferation with and without plasma treatment.

    plasma-surface-modification-of-nanostructured-surfaces-of-marine-based-scaffolds-and-membranes-for-enhanced-bioactivity
  • In order to facilitate remote experimentation for multiple users, the project demonstrates the possibility of real-time shared access for multiplexing the usage of control and acquisition hardware. The project also investigates and develops the architecture for scaling up the experiments by effective timesharing of available resources to be made available to large scale of users.

    mu-share-multi-user-realtime-shared-access-platform-for-remote-experimentation
  • This project has been developing nanostructured thin film electrical storage materials with high surface area and storage capacity. A range of nanomaterials is being investigated, such as, nanocarbon, metal oxides and on variety of processing techniques & deposition methods.

    combining-solar-cells-with-supercapacitors-and-batteries-integrated-nanomaterial-based-photovoltaic-storage-devices
  • The tumour hierarchical model proposes origin of cancer from a small population of cells having properties of stemness like self renewal and pluripotency. Although, cancer stem cells (CSCs) have been identified in leukemia and solid tumours by surface markers, there is variability in their specificity for isolation of CSCs in a specific tumour.

    biology-of-cancer-stem-cells-2
  • Both India and Brazil have a major need to improve their education, health, and support available during disasters, especially in areas with limited connectivity. The goal of this project is to use wireless communication networks for developing enhance healthcare system impart education, build cooperation,promote collaboration, and facilitate innovation among Indian and Brazilian students, professionals, and researchers.

    wireless-networks-and-techniques-with-applications-to-societal-needs-indo-brazil-collaborative-research-project-
  • Drug discovery is currently in an exciting phase where conventional methodologies are being ably complemented by ‘omics’ approaches due, in part, to the greater accessibility of the newest generation of high-throughput platforms and technologies. At the Cancer Discovery Biology Laboratory, work is done towards making the identification of oncology clinical biomarkers more feasible through state-of-the-art pharmacogenomic and proteomic techn

    cancer-discovery-biology
  • Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory. These labs focus on helping students retain the real feel of a laboratory, while conducting the experiment from an internet-enabled computer terminal, much in the same way as is done, in a real lab.

    virtual-amrita-laboratories-in-biotechnology
  • This project provides mobility funding for joint facility utilisation visits between ACNS and University of Zurich on the project entitled, “Anti-cancer Applications of Chitosan and Polyoxometalate Nanocomplexes”.

    joint-utilization-of-advance-facility-juaf-program-isjrp-indo-swiss
  • PI: Dr. Duraisamy Kumaresan
    Co-PIs: Dr. Nikhil K. Kothurkar, Dr. Yamuna
    Sponsors: DRDO, ER & IPR
    Dept./Center: Solar Energy and Optoelectronics Laboratory
    Start Date: July 2010

    new-and-efficient-photosensitizers-for-nanocrystalline-tio2-based-dye-sensitized-solar-cells
  • Asymptomatic hyperparathyroidism is not well recognized in Indian population and is considered rare. Estimation of serum calcium level is not part of routine comprehensive health checkup.

    population-survey-of-asymptomatic-hyperparathyroidism-in-kerala
  • Fusion transcripts are known to occur in cancerous cells across a range of cancers and might play important roles in the pathophysiology of cancer. In developing newer strategies to combat cancer, therapeutic knock down of fusion transcripts by RNA interference technology is being considered for its potential benefits in targeting cancerous cells.

    fusion-transcripts-in-cancer-and-the-potential-to-inhibit-by-rna-interference
  • An initiative of the Ministry of Human Resources Department under the National Mission on Education through ICT, Amrita's Collaborative Accessibility Platform for Virtual Labs (Amrita CAP-VL) provides a framework for the development and deployment of distributed virtual labs that use diverse software and interfacing technology. It support the system architectures for remote equipment labs and addresses scheduling, networking, security and scalability.

    amrita-collaborative-assessment-platform-for-virtual-labs-cap-vl
  • The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer. This will enable a better understanding of miRNA dysregulation and identify novel biomarkers for preventive or therapeutic intervention in liver cancer.

    modulation-of-microrna-and-protein-signatures-in-hepatocellular-carcinoma-by-chemopreventive-phytochemicals
  • The crucial role of hands on experiments in the STEM curriculum to motivate and deepen understanding is universally accepted. In India, many schools lack equipment in science labs and in rural areas there is a lack of teachers depriving students of STEM education.

    measuring-learning
  • The project 'Oncogene Sensing and Finger Printing from Saliva Using Nanotechnology' deals with Raman spectroscopic detection of cancer biomarkers from human tissues and bio-fluids.

    oncogene-sensing-and-finger-printing-from-saliva-using-nanotechnology-enabled-using-raman-spectroscopy
  • A project under MHRD ERP, Amrita Display Information and Visualization Engine (Amrita DIVE) uses ROLAP technology to gather information from multiple LMS/CMS engines and then uses advanced visualization techniques to provide graphed information that allows educators to understand the pattern and usage of content used by Indian universities. 

    amrita-display-information-and-visualization-engine-amrita-dive-
  • The main objective of this project is to monitor and control the machining process during ultra-precision machining of titanium alloys. Using advanced signal processing techniques, the hidden information in the acoustic emission signal is extracted to predict the machining parameters with high levels of accuracy. The features from the signal are extracted and a set of predominant features is selected using dimensionality reduction techniques.

    process-monitoring-and-control-of-ultra-precision-machining-of-titanium-alloys
  • This project involves a controlled and well-characterized material process development for the preparation of carboxymethyl chitin and chitosan derivatives for applications in the biomedical area. Chitin and Chitosan are known to be natural biopolymers and are non-toxic, biodegradable and biocompatible. In the last decade, chitin and chitosan derivatives have become the focus of interest in biomedical and biopharmaceutical research.

    preparation-of-carboxymethyl-chitin-and-chitosan-derivatives
  • Docking studies are computational techniques for the exploration of the possible binding modes of a substrate to a given receptor, enzyme or other binding site. The application of computational methods to study the formation of intermolecular complexes has been the subject of intensive research during the last decade.

    computational-chemistry-amp-molecular-docking-studies
  • This project involves application of a new technique using a proteomics approach to sensitively identify molecules of therapeutic significance in Cerebral Spinal Fluid (CSF) samples.

    identification-of-novel-cell-surface-molecules-of-therapeutic-significance-in-central-nervous-system-leukemia
  • The project titled "Process Monitoring & Control of Ultra Precision Machining of Ti6 Al4 V Alloys" is funded by DRDO. 

    process-monitoring-amp-control-of-ultra-precision-machining-of-ti6-al4-v-alloys
  • Virtual Physics Labs have sophisticated simulations that enable the users to conduct a vast array of physics experiments. Users can work with interactive electronic components to create electric circuits, conduct oscillatory experiments on different planets, or interact with specialized virtual equipment such as a Laser Beam Emitter. All this becomes available to the user simply with a computer and an internet connection.

    physics-virtual-labs
  • VALUE Virtual Chemistry laboratories introduce a new dimension to the chemistry lab. Virtual labs provide a number of benefits to both the student and teacher. Virtual experiments allow educational institutes to take advantage of vast savings from reduced consumption in chemical supplies and reduced costs that result from accidental breakages.

    chemistry-virtual-labs
  • Amrita University is creating comprehensive Mechanical Engineering Virtual Labs in the following areas: Mechanics of Solids, Wind Energy, Solar Thermal Energy, and Energy Storage. Each lab consists of 8 to 10 experiments. All experiments have a common web platform where students can view experiments via a web interface happening in real-time with a web-cam. 

    mechanical-engineering-virtual-labs
  • Virtual Lab: Amrita Vishwa Vidyapeetham is transforming the face of higher education and research, through a revolutionary new educational tool – virtual labs. The VALUE Initiative is a project dedicated to developing these virtual labs in various science and engineering disciplines. Virtual labs are media-rich online learning environments, which allow users to conduct physical laboratory experiments in a computer-simulated environment. This innovative new educational technique is enabling experimentation beyond the boundaries of traditional laboratories

    value-virtual-simulation-labs
  • Comprehensive study of threats, their operational architecture, and adoption of threat modeling for their classification, form the foundation for development of secure technologies for cloud. Cloud platforms today assist providers in controlling and managing the customer VMs. In addition, they also help monitor and manage cloud performance. 

    threat-modeling-trust-modeling-and-development-of-secure-platform-in-cloud-environments
  • There are more than 2.5 million cancer patients in India at any given time, of which the frequency of breast and ovarian cancer cases has increased. Although there are many possible reasons, reversible phosphorylation of proteins, mediated by receptor tyrosine kinases (RTK) such as VEGF and HER2/neu receptors play a crucial role on different cellular processes associated with cancer pathogenesis.

    cancers-treated-with-vegf-and-her-2-neu-receptor-tyrosine-kinase-inhibitors

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