Course

Unit I

Medicinal Chemistry
Introduction, drugs classification of drugs mechanism of drug action. Drug-receptor complex, nomenclatureagonist.

Unit II

Physicochemical Properties of Drugs in Relation to Biological Action
Solubility, Partition coefficient, dissociation constant, hydrogen bonding, ionization, drug shape, surface activity, complexation, protein binding, molar refractivity, bioisosterism stereo chemical aspects of drug action.Enzymes, hormones and Vitamins – representative cases, nomenclature, classification and characteristics of enzymes, mechanism of enzyme action, factors affecting enzyme action, co-factors and co-enzymes, enzymes in organic synthesis, mechanism of enzyme catalysis, enzyme inhibition. Hormones and vitamins representative cases.

Unit III

Essentials of Drug Design
Molecular mimetics, drug-lead modification, drug design using QSAR and computer assisted design, assessment of drug activity, receptors and drug action, mechanism of drug action, drug metabolism pathways, Drug potentiation, drug antagonism and drug resistance

Unit IV

Medicinal Agents from Natural Products
History of the use of natural products as therapeutic agents, medicinal plants, active principle, Isolation methods of alkaloids, terpenes, antioxidants, natural oils from plants.

Unit V

Medicinal Agents
Medicinal agents belonging to alkaloids, steroids, polypeptides, modified nucleic acid bases, sulphonamide and sulpha drugs, antibacterials – sulpha drugs, substituted sulphonamides, anticonvulsants, anticoagulants, antiamoebic agents, antihelmintic agents, anti-malarial agents, diuretics and cardio vascular agents, , medicinal agents affecting CNS, analgesics, antipyretics, antiseptics and disinfectants, Histamine and anti-histaminic agents.Infectious and non-infectious diseases (malaria, AIDS, Cancer) introduction, mechanism of action types of cure.

• CO1: Explain the fundamental principles of medicinal chemistry including drug classification and mechanism of drug action.
• CO2: Analyze the physicochemical properties of drugs and their influence on biological action and the machanism and influence of various factors in the context of enzyme action.
• CO3: Apply QSAR and computational approach for design of drugs and to assess drug activity, potentiation, antagonism and resistance.
• CO4: Explain the extraction techniques of therapeutic agents from natural products.
• CO5: Explain the different classes of medicinal agents and their therapeutic application and mechanism of action.  

Textbooks

1. John M beak and John H Block, ‘TWilson, O. Gisvold and R.F. Deorge –Textbook of Organic, Medicinal and Pharmaceutical Chemistry’, 7^th edition, J. B. Lippincott Williams and Wilkons Company, 1977.
2. Burger,‘Medicinal Chemistry’, 3^rd edition, Wiley Interscience, 1970.
3. K. Ahluwalia and Madhu Chopra, ‘Medicinal Chemistry’, Ane Books pvt Ltd, 2008.

References

1. Kothekar, ‘Essentials of Drug Designing’, 14^th edition, Dhruv publications, 2005.
2. K. Ahluwalia, Lalita S. Kumar and Sanjiv Kumar, ‘Chemistry of Natural Products’, Ane Books India.
3. P. Graham ‘An introduction to Medicinal Chemistry’, 3^rd edition, Oxford University Press,  2005.