Course

LIST OF EXPERIMENTS: I. Synthesis of medicinally important compounds/IntermediatesPreparation of 2,3-DiphenylquinoxalinePreparation of 7- Hydroxy 4- Methyl CoumarinMicrowave-assisted synthesis of PhenytoinMicrowave-Assisted Synthesis of AspirinPreparation of BenzocainePreparation of phenothiazine from diphenylaminePreparation of benzimidazoles from OPDAII. Assay of some medicinally important synthesized compoundsDetermination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors, and acceptors for the class of drugs course content using drug design software (Swiss ADME) Drug likeliness screening (Lipinski RO5) (Demo)SEMINAR/ASSIGNMENTS:Identify ten existing therapeutic agents which are used for drugIdentify the newly approved drugs under each of the following categories, mention the advantages of newly approved drugs over existing drugs and their brand namesAntifungal AgentsAntitubercular agentsAntiprotozoal agentsAnthelmintic agentsAntimalarial agentsAntineoplastic agentsAntiviral agents and Anti-AIDS agents

TEXT BOOKS:John MB, John Wilson and Gisvold?s Textbook of Organic, Medicinal and Pharmaceutical Chemistry. 12th ed. New York, Philadelphia: Wolters Kluwer, Lippincott Williams & Wilkins; 2011.Victoria, Roche, David AW, Thomas Foye?s Principles of Medicinal Chemistry. 8th ed. New York, Philadelphia: Lippincott Williams & Wilkins, Wolters Kluwer; 2019.Ilango K, Valentina Medicinal chemistry for Pharm D.1st ed.Keerthi Publishers;2012.Patrick L. An Introduction to Medicinal Chemistry. 4th ed. New York: Oxford University Press; 2009.Mann G & Saunders B C. Practical organic chemistry. 4th ed. India: Pearson Education India; 2009(Practical)Vishnoi K. Advanced Practical organic chemistry. 3rd ed. India: S. Chand; 2010 (Practical).of India. Indian Pharmacopoeia 2022 (Volume I ,II, III &IV),9th ed.. India: The Indian Pharmacopoeia Commission; 2022. (Practical) REFERENCE BOOKS: Current Index of Medical Specialities (CIMS) and MIMS India, MIMS, E. Morgan Publications (I) Pvt. Ltd, New Delhi-19.Sriram D, Yogeeswari Medicinal Chemistry.4th ed. Dorling Kindersley(India) Pvt Ltd;2013.Welly E., M.E. Walffred. Burger?s Medicinal Chemistry, 1 ? 8. 8th ed.Newyork: Wiley Interscience Publication;2005.Pandeya SN, Dimmock JR, An introduction of Drug 2nd ed. New Age International, 2019.Brian F, Antony J.H, Peter W.G.S & Austin R.T. Vogel?s textbook of Practical Organic Chemistry. 5th ed. India: Pearson Education India; 2003(Practical) *Latest edition of the text books & reference books can be referred