Publication

Abstract : Hitherto, life-sustaining mechanisms were primarily understood within the purview of:(i) intelligent cellular/organellar membranes guarding/maintainingtheir internalmilieu deterministically, and (ii) the cellular activities beinggoverned by directional information-flow via thecentral dogma. In thisschema, cellular coherence (inter-molecular networking to achieve functional unitization) and homeostasis/electrophysiology wasexplainedbythe concentration-dependentinteraction dynamicsof catalytic enzymes-substrates, electron donors-acceptors, signalling receptors-ligands, channels-ions, antibodies-antigens, etc.Suchtreatments entailedselective/specificand topology-based(affinity-driven)stoichiometricinteractions.Also, only the impact of externalradiations (like X-rays, UV-Vis-IRlight, micro/radiowaves, etc.) on living systemshave found prominence in biomedical literature, with lesser information on internally generated or readdressedlow/high-frequency radiations. The abovelong-standing paradigm has witnessed a major upheaval in the last decade with the unravelling of murburn concept, which postulatesthat diffusible reactive species (DRS)and murzymes (proteins that recruit DRS in routine functions)are a fundamental pivot of life that aidcatalytic moiety-/electron-transfers, phase-changes, post-translational modifications, etc. within the cells, thereby servingdiverseagenda of itsfunction. The murburntheorization solicits stochastic and variable“molecule-unbound ion-radical/radiation interactions”,provides adequate energy differentialsfor powering cellular processes,and explainswhy oxygen became the elixir of life. Herein, we projecttangible framework/examplesof how murburn concept could afford a seamlessinterlacing of man-made synthetic componentswith biological systems, particularly within the contexts of bioenergetic, metabolic and sensing-response agenda. We also discuss mandates wherein analog-digital conversions could be achieved, and project the scope and limitations of murburn-based approach in futuristic bionic-cyborg technology.