Qualification: 
Ph.D

Dr. M. P. Narmadha joined Amrita School of Pharmacy in April 2021. She completed her Bachelor's Degree in Pharmacy from Madurai Medical College, Madurai Kamarajar University and her Master's Degree in Pharmaceutics from the Department of Pharmaceutical Sciences, Institute of Technology, Banaras Hindu University, Varanasi of Uttar Pradesh, which is the first Pharmacy institution in our country. Her M.Pharm. project work titled "Formulation and Evaluation of Clonidine Transdemal Patches” was the first of its kind in the year 1989. She completed her Ph.D. in Pharmaceutical Sciences from Tamilnadu Dr. MGR Medical University in 2008. Her doctoral dissertation was titled "Comparative Study of Pharmacotherapy in Allopathy with Alternative Systems of Medicine in Rheumatoid Arthritis Patients". This thesis work includes the clinical profile of RA, biochemical investigation of oxidative stress and antioxidant level, antibodies for Epstein Bar Virus, Immunological investigation of the quantitative expression of TNF- alpha. She has more than 39 years of teaching and research experience inclusive of eight years of Industrial experience in R& D, Quality control Department and Clinical Research and has several publications in national and international journals. She is a recognized trainer for Pharmacovigilance associates of PVPI, IPC, Gaziabad and auditor of Pharmacovigilance Peripheral centers in India. She has conducted Community Pharmacy Programs to create awareness on the proper use of medicines and on issues associated with self-medication in the rural populations in and around Madurai. Community Pharmacy camps for early identification of Diabetes and Hypertension in Thichengode, Educating school children about epidemic diseases and their prevention in Thiruchengode schools, Tamilnadu. Pharmacy Exhibition for College students on various lifestyle diseases, HIV, Dos and Dont’s of Medications and First aid for Thiruchengode Arts and Science and Engineering college students, Awareness camps for tribal population in Attapadi village hubs, and Community surveillance camps at Attapadi,Kerala.

Additional Qualification

  • PG Diploma in Biostatistics from Madurai Kamaraj University in the year 2008
  • PG Diploma in Business Management from Indian Merchants Chambers, Mumbai in the year 1985
  • IRCA Certified ISO 9001-2015 Lead Auditor from March,2021

Dr. Narmadha's current research focus is on Statin induced Hyperglycemia, Genetic variation causing adverse drug reactions.

Research Findings

Doses of chemotherapeutic agents have to be titrated to suit Indian cancer patients.

Hyperlactemia induced by HAART in HIV patients was studied and dose titration is recommended for Indian HIV patients 

Diabetes Mellitus 

Simple estimation of Fibrinogen levels to predict the risk of cardiovascular diseases in Diabetes Patients. Diabetic patients with Peripheral arterial diseases ( PAD)identified by Ankle Brachial Index(ABI) also showed increased fibrinogen levels confirming the importance of fibrinogen estimation to rule out CVD in Diabetics.

Diabetics affects the pharmacokinetics of antitubercular drugs and there is a delayed response to anti Tubercular agents in diabetics.

DLVO diffusion study of CO in Diabetics with COPD and COPD patients without Diabetics has clearly shown poor diffusion capacity of alveolar membranes indicating membrane thickness caused by Diabetes . In addition to regular monitoring for micro and macrovascular complications , it is necessary to screen diabetic patients for lungs diffusion capacity. 

Regular testing on microalbuminurea in Diabetics would help to assess the risk of Proteinurea , because   after the onset of Proteinurea patients are left with drug treatment failing which they end up with dialysis. 

Patients on Haemodialysis have to be thoroughly monitored for Parathyroid levels in addition to haemoglobin variability testing ,high parathyroid levels as the main factor for mortality in Haemodialysis patients.

Metformin induced Hyperhomocystenemia was confirmed , patients can be supplemented with supplement of Folic acid 2.5mg

MI: Hyperhomocysteinemia is the lone significant  risk factor to cause Myocardial infarction (MI) in young adults  without any conventional risk factors.

Gynaecology and Obstetetrics

Standard dose of 150 IU HMG causes ovarian hyper stimulation syndrome and reduces the success rate in conception whereas a medium dose of 112.5 IU  HMG induces ovulation optimally and success rate in conception is good.

Two doses of Betamethasone 12mg 24 hours apart to Prenant mothers with risk prevents respiratory distress Syndrome(RDS) in Pre term neonates.

COPD- Fluctuations in Magnesium levels is indicative of mortality in hospitalised COPD patients.

Head trauma /Consanguineous marriages are the main causative factors for seizures.

Publications

Publication Type: Journal Article

Year of Publication Title

2020

Dr. M.P.Narmadha, P.S, H., Tomy, M., Naushad, N., and .S.Sreelakshmi, M., “Antenatal use of Corticosteroids to Prevent Respiratory Insufficiency in Preterm Babies ”, Asian Journal of Pharmaceutical Education and Research, vol. 8, no. 4, 2020.

2019

Dr. M.P.Narmadha, disilva, J., S, V., and S, R., “Relationship between Sputum Smear Grading and Smear Conversion Rate and Treatment Outcome in the Patients of Pulmonary Tuberculosis Undergoing Dots in Kerala - A Prospective Cohort Study”, Saudi Journal Medical Pharm Science, 2019.

2018

Dr. M.P.Narmadha, S, U. A., A, M., Saravanan R., and D, S., “Assessment of DNA damage in pulmonary tuberculosis patients by comet assay”, Indo American Journal of Pharmaceutical research IAJPR, vol. 4(3), pp. 1574-1580, 2018.[Abstract]


To determine the extent of cell damage in Pulmonary Tuberculosis patients with the help of comet assay. Study type: Prospective study. Place and duration of study: Tiruchengodu Govt. Hospital from September 2011 to April 2012. Patients and Method: Blood samples were collected from 40 subjects [Control (Go), newly diagnosed TB patients (G1), Three months treated TB patients (G2), Six months treated TB patients (G3). n=10 subjects in each group]. Peripheral blood samples were collected, embedded in agrose gel, lysed in high ionic strength solution with Triton X-100, and then electrophoresed at pH>13, Ethidium bromide stained were then subjected to analysis under Fluorescent microscope. Result: Subjects of newly diagnosed TB (G1) patients did not show any remarkable cell damage as compared to control (G0). Extent of cell damage in Three months treated TB patients (G2) and in Six months treated TB patients (G3) was extremely significant (p <0.0001). From quantitative comet metrics, comet length which shows extremely significant difference in males compared with females. P value is <0.0003. Discussion: Extent of cell damage was observed significantly high in Anti-tubercular drug treatment patients (ie) three months treated and six months treated TB patients. Due to their social habits also DNA damage was significantly increased in tuberculosis patients.

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2018

Dr. M.P.Narmadha, Menon, A. S., and M, A., “Study of Fibrinogen Level in Type 2 Diabetes and Its Influence on Peripheral Arterial Disease”, Saudi Journal Medical Pharm Science , vol. 04, no. 12, 2018.

2017

S. Adiody, S, F., Dr. M.P.Narmadha, and Varghese, P. R., “Dyselectrolytaemia in Stable and Acute Exacerbation Chronic Obstructive Pulmonary Disease Patients- a Cross Sectional Study”, Journal of Evolution of Medical and Dental Sciences, vol. 6, pp. 2296-2299, 2017.[Abstract]


There were changes in levels of sodium, potassium and magnesium in AECOPD patients compared to stable COPD patients. Timely screening with earlier detection and intervention would be useful in controlling AECOPD

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2017

Dr. M.P.Narmadha, Adiody, S., Menon, A. R., and R, V. P., “Impact of Diabetes Mellitus on Pulmonary Function Tests in COPD Patients”, International Journal of Contemporary Medical Research, vol. 4, 2017.[Abstract]


Introduction: Chronic Obstructive Pulmonary Disease is considered as a disease that goes beyond lung involvement giving it an expression of a multisystemic inflammatory disease. The association of reduced lung functions and diabetes mellitus has been described for many years suggesting that the lung could be a target organ in diabetes mellitus. In this study, we aimed to assess the pulmonary functions in chronic Obstructive Pulmonary Disease patients with normo-glycemia, Chronic Obstructive Pulmonary Disease with diabetes mellitus and diabetes mellitus patients. Material and Methods: The study was conducted in Jubilee Mission Medical College and Research Institute, Thrissur. After the inclusion criteria were met, patients were divided into 3 groups each 20 patients. The procedure of spirometry was performed and results were analysed. Results: Lung functions were the least in patients with Chronic Obstructive Pulmonary Disease and diabetes mellitus. Diabetes mellitus was also an independent risk factor for reduced lung functions as was seen in non smoking diabetic females. Conclusion: Pulmonary functions are reduced in DM independent of smoking

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2017

Dr. M.P.Narmadha, njattmkalayil, N., and George, M., “Effect of Anti-tubercular Drugs and Impact of Glycemic Status in Patients with Tuberculosis and Concomitant Diabetic- Tuberculosis Patients”, Indian Journal of Pharmacy Practice, vol. 10, no. 2, 2017.[Abstract]


India is a key nation which is endemic and epidemic to tuberculosis and diabetes. An association between diabetes and TB is biological plausible, where diabetes impairs the immune system and making it harder for the body to fight against infection. Methodology: Patients on DOTS therapy in continuation phase of anti-TB therapy, Patients with TB and Diabetes and Patients with TB alone were included in the study. Blood samples were collected and Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG) and Glycated Hemoglobin (HbA1c) were measured to understand the glycemic status and its impact on TB treatment outcomes. Results: Our study confirms the fact that type II diabetes is a strong risk factor for tuberculosis and is associated with a slower response to TB treatment and a higher mortality rate. Incidence of TB is greatest among those with conditions impairing immunity such as DM. Diabetes impairs the immune system, making it harder for the body to fight against infection.

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2016

Dr. M.P.Narmadha, Fezil, M., and Benson, B., “Influence of occupational noise on Insulin, Blood glucose, Homocysteine, Blood pressure and Heart rate”, International journal of Pharmacy Research, 2016.

2015

Dr. M.P.Narmadha, Karthikumar, B., .n.n, R., .a, palanisamy, Ganapathy, S., and N, M., “Effect of folic acid on serum homocysteine levels in patients with cardiovascular diseases (cvd)”, International journal of pharmacy & pharmaceutical research ijppr, vol. 4, no. 1, 2015.

2014

Dr. M.P.Narmadha, R., N., R., A., and N., M., “Analysis of organophosphates intoxication in a tertiary care hospital”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 5, pp. 174-182, 2014.[Abstract]


As the mortality rate is found to be high in organophosphorous poisoning, the study was aimed at studying the socio demographic pattern and mode of presentation of organophosphorous (OP) intoxication in Madurai, Southern Tamil Nadu. A prospective study of fifty organophosphorous compound poisoning cases, admitted through the emergency department of Government Rajaji Hospital, Madurai, were evaluated in the study. Treatment outcome was studied and reduction in cholinesterase activity was estimated to confirm the exposure and assess the severity of OP poisoning. Among the 50 cases evaluated,39 (78%) patients were males, 11(22%) were females and the mean age was 35.82 ±1.779 years. Thirty two (64%) percent of cases were illiterate and twenty six (52%) of the patients were in the lower middle socioeconomic status. Mean arrival time to the hospital after poisoning was 2.609 hours. Exposure routes were gastrointestinal in all the patients. The mortality rate was 34% and related to either the ingestion of higher doses or delay in approaching the hospital for emergency management. There was a significant reduction in serum cholinesterase level (2.5120X107± 1.592 mol/min/mg protein) (P<0.05) after OP poisoning. The extent of depression reflected the severity and was found to be reverted back towards normal upon treatment. Fatal issue is often related to causes of poisoning (suicide vs. non-suicide), delayed hospitalization and delay in diagnosis or an improper management. These findings call for a shift in emphasis in educating the masses towards first-aid care for intoxication and further necessitate the need for strict regulation of their use and adequate medical management monitoring for serum cholinesterase level will help to bring down the mortality rate.

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2014

Dr. M.P.Narmadha, Preeth, S., Tsegai, S., MaekeleTsgehannes,, and MussieEssietGide, “Treatment pattern and glycemic control of oral hypoglycaemic drugs among type II dm patients in eritrea”, Pharmacologyonline, 2014.[Abstract]


The present retrospective study aimed to explore the treatment pattern and glycemic control of oral antidiabetic drugs among type 2 diabetes mellitus patients in Asmara, Eritrea. This study was undertaken in the Diabetic Unit of Helibet Referral Hospital, Asmara. Two hundred case files were included in this study after they ran across the inclusion criteria of patients age of ≥ 20 years, who identified with type 2 diabetes and who underwent fasting plasma glucose (FPG) testing at least 3 times. The information collection was performed over the period of five months. The most usually prescribed anti-diabetic medications were sulfonylureas (Glibenclamide -131 and Glimipride - 60) and Metformin (74) either alone or in combination. Monotherapy was prescribed more (135, 67.5%) than combination therapy (65, 33.5%). No significant difference in FPG reduction was found among monotherapies. Whereas, in combination therapy Glibenclamide + Metformin combination was found to be more effective (p = 0.01). No treatment variations observed between current clinical practice and Eritrean National Treatment Guideline (Edition 2003) and Treatment Algarithm of International Diabetes Federation Eritrea (Africa region). On the other hand, just 37% prescriptions were adherent to American Diabetic Association’s recommendation concerning Metformin as first-line monotherapy. In conclusion, Biquanides and sulphonyl ureas were prescribed and none other oral hypoglycemic drugs were ordered. Only, Multiple doses of basal Insulin have been prescribed for patients with inadequate glycemic control. © 2014, SILAE (Italo-Latin American Society of Ethnomedicine).

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2013

A. Palanisamy, Rajendran, N. N., Dr. M.P.Narmadha, and Ganesvaran, R. A., “Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy”, Epilepsy & Behavior, vol. 26, pp. 165-169, 2013.[Abstract]


Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy. Apolipoprotein E ε4 allele has been reported to play a role in severe memory impairment that ultimately progresses to Alzheimer's disease (AD); however, knowledge about its role in cognitive impairment in patients with epilepsy is lacking. Our study proposes the possible involvement of the APOE ε4 allele in cognitive impairment in patients with epilepsy which is further worsened by phenytoin monotherapy. Assessment of the APOE ε4 allele in a population with epilepsy will help to identify the patients vulnerable to cognitive impairment and, therefore, the corrective therapy that needs to be addressed.

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2013

M. .Sudheerkumar, .Palanisamy, A., Dr. M.P.Narmadha, Anuradha, M., .Nagajothi, N., and .Haribabu, N., “Central Obesity: A risk factor for Metabolic syndrome in South Indian population”, International research journal of Pharmacy , vol. 3(9), pp. 248-52., 2013.

2013

M. Fezil, Dr. M.P.Narmadha, and Benson, B., “Influence of occupational noise on Insulin, Blood glucose, Homocysteine, Blood pressure and Heart rate”, International Journal of Pharmaceutical and Clinical Science , vol. 3(2), 2013.

2012

J. M, Sengodan, A., Dr. M.P.Narmadha, and Malampati, S., “A comparative effect of atorvastatin with other statins in patients of hyperlipidemia”, Indian journal of pharmacology, vol. 44, pp. 261-3, 2012.[Abstract]


The objective of the study was to evaluate the safety and efficacy of atorvastatin compared with simvastatin and pravastatin in patients of hyperlipidemia. This was a randomized, parallel group, open-label study conducted at KG hospital, Coimbatore, Tamilnadu, India. Twenty hyperlipidemia patients each taking atorvastatin 20 mg, pravastatin 20 mg and simvastatin 20 mg tablets were selected for the study after clinical and baseline investigations. The patients were reviewed after 3(rd) and 5(th) month of statin therapy for lipid profile. The liver enzyme levels (SGOT, SGPT, ALP), albumin, bilirubin, protein and biochemical infraction parameters (Creatine Kinase, Creatine Kinase - Myocardial Band) after 5(th) month of treatment with statins were also reviewed. The results showed that atorvastatin significantly reduced the lipid levels (LDL-C, TC, TG, VLDL) when compared to simvastatin and pravastatin after 3(rd) and 5(th) month of treatment. Atorvastatin increased the HDL-C levels significantly when compared to simvastatin and pravastatin after 5 months of treatment. Atorvastatin also significantly reduced the CK levels when compared to pravastatin but no increase in liver enzyme levels was observed. The study showed that atorvastatin is more effective when compared to simvastatin and pravastatin in patients with hyperlipidemia.

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2012

Dr. M.P.Narmadha, .N.Rajendren, N., and Varghese, N. Elsa, “Level of insulin and ibubrufen in cancer pain patients”, International j of biological and pharmaceutical services, vol. 3(1), 2012.

2012

G. S, Dr. M.P.Narmadha, Paranjothy, D., and B, L. Narayanan, “Comparison between nifedipine and methyldopa on blood pressure and fetal outcome in pre-eclampsia”, International Journal Of Advance Pharmaceutical And Biological Sciences, vol. 2, no. 3, 2012.[Abstract]


Objective: To compare the effects of Nifedipine and Methyldopa on maternal blood pressure

as well as fetal outcome in patients with Pre-eclampsia.

Design: A randomized control study.

Subjects: A total of 120 patients with PIH were allocated alternatively to either group. The

patients in Group A received methyldopa (250 mg/day); Group B received methyldopa along

with atenolol (25 mg/day) and Group C received nifedipine (10 mg/day).

Measurements: Blood pressure, blood counts, kidney function tests, lipid profiles, urin

alysis, Apgar score, baby birth weight, in relation to parity, recurrent fits, mode of delivery,

length of hospital stay and Perinatal outcomes were noted.

Results: The mean blood pressure on entry was 152/104 mm/Hg in the group. During

treatment the mean diastolic pressure was significantly reduced in nifedipine group (16%)

p<0.0001. There were no changes in lipid profiles were triglycerides (178.2 7.239) and high

density lipoprotein (32.225 9.614) p-0.0285 were increased. Platelet count was decreased in

all treatment groups with p value 0.0003. Serum creatinine was elevated (1.71 0.0873) and

uric acid with mean (7.705 0.0401). The results showed no difference between the groups

with respect to mode of delivery and baby birth weight.

Conclusion: The results showed that nifedipine treatment lead to a better BP control and a

safer fetal outcome with reduction of blood pressure, proteinuria, serum creatinine level and

platelet count in normal range. Apgar score was better for nifedipine when compared to

methyldopa or methyldopa along with atenolol.

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2012

N. N.John, Dr. M.P.Narmadha, and R. kumar, M., “Assessment of cardiovascular risk in pre and post menopausal hypertensive women”, International research journal of Pharmacy, vol. 3(7), 2012.

2012

Dr. M.P.Narmadha, M., V., and Rajendran, N., “Assessment of chemotherapy induced amenorrhea (CIA) in hormone receptor positive premenopausal women with breast cancer”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 3, pp. 97-106, 2012.[Abstract]


Chemotherapy induced amenorrhea (CIA) is associated with improved disease free survival (DFS) in women with ER/PR-positive breast cancer and no association was observed in those with ER/PR-negative tumors. To assess the incidence of chemotherapy induced amenorrhea (CIA) with the addition of taxanes to anthracycline regimen in premenopausal patients diagnosed as hormone receptor positive breast cancer. A retrospective study was carried out at Amala cancer hospital & research centre, Kerala. Patients were placed in to two subgroups depending on the type of chemotherapy that had been administered: anthracyclines regimens either with or without taxanes. Out of 50 ER+/PR+ patients considered, 36 were on anthracycline regimen alone (Group 1)and14 were on anthracycline + taxane regimen (Group 2) and.100% of group 2 and (75%) of group 1 experienced CIA (P=0.0470, RR=1.333). The permanency of CIA was also high in group 2 than in group 1. (64.2% Vs 48.1%) (P=0.5100, RR=1.335). A slight increase in CIA was prevalent in women >40yrs (89.6% Vs 71.4%) (P=0.1404, RR=1.255) The permanency of CIA was also high in patients who were >40 yrs old (69.2% Vs 26.6%) (P=0.0115, RR=2.596) Our study concluded the higher incidence of CIA in Anthracycline + taxane group than Anthracycline alone that can increase disease free survival in ER+/PR+ breast cancer patients.

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2012

J. A.K., Dr. M.P.Narmadha, R., R., N., M., and Amirthalingam, P., “Comparative pharmacokinetic study of rifampicin and isoniazid in intensive and continuation phase TB treatment”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 3, pp. 354-360, 2012.[Abstract]


Altered pharmacokinetics of anti tuberculosis drugs may contribute to an increased risk of tuberculosis treatment failure for TB population.Here we examined and compared the pharmacokinetics of rifampicin and isoniazid in the intensive and continuation phase of tuberculosis treatment.Previously we found that rifampicin and isoniazid exposure was lower in intensive phase treatment when compared to continuation phase. For the study purpose 25 patients each from intensive and continuation phase were included in a government hospital setting. Pharmacokinetic sampling was performed for rifampicin and isoniazid in patients after light breakfast. The assessments were done for 50 tuberculosis patients after careful observation. There is much differences in the area under the concentration- time curves of drugs in plasma from 0 to 8 h(AUC0-8),maximum concentrations of drug in plasma (C max),the time to C max, and half-lives of Rifampicin, Isoniazid were found between intensive and continuation phase tuberculosis treatment. Biological half life of both rifampicin and isoniazid was lowered in both phases of treatment leaving a short exposure of drug.Compared to continuation phase AUC(0-8hrs) of rifampicin was less in intensive phase (32.005μg hr/ml, P= 0.0266), and AUC of isoniazid also less in intensive phase when compared to continuation phase (35.57μg hr/ml,p=0.1354). The study reveals that there is reduced exposure to rifampicin and isoniazid in intensive phase ,compared to continuation phase. This could be one of the reason for relapse or recurrence of TB.

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2011

Dr. M.P.Narmadha, “Effect of Insulin Therapy in type – 2 Diabetes in improving Beta cell function and glycemic control compared with oral anti diabetic agents with or without insulin in routine clinical practice. ”, Indian journal of Pharmacy Practice, vol. 3, 2011.

2011

M. Ramesh, Dr. M.P.Narmadha, S, R., Alvin, J., and Babu, D., “Effect of a Diabetes Counseling Programme on Knowledge, Attitude and Practice among Diabetic Patients in Erode District of South India”, Journal of young pharmacists : JYP, vol. 3, pp. 65-72, 2011.[Abstract]


The prevalence of diabetes in India has grown over the past decade. Diabetic patients develop complications due to poor awareness regarding the disease and inadequate glycemic control. Patient education is the most effective way to lessen the complications of diabetes and its management. A total of 207 (85 males and 122 females) type 2 diabetes mellitus patients were enrolled and randomized into test and control groups. Patients in the test group received counseling at each visit and information leaflets from the pharmacist; the control group patients received counseling and information leaflets only at the end of the study. A validated knowledge, attitude, and practice (KAP) questionnaire was administered to both test and control group patients at baseline and at final follow-up to assess awareness regarding disease management. Glucose and lipid levels were also evaluated at baseline and final follow-up in both the groups. At the end of the study, the KAP score of test group patients improved significantly (P<0.0001), whereas no significant changes were observed in control group patients. The postprandial blood glucose (PPBG) levels decreased significantly in the test group. Total cholesterol (TC), triglycerides (TGL), and low density lipoprotein levels (LDL) also showed a decrease in the test group. Thus, our study reveals that pharmacist counseling might be an important element in diabetes management programs.

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2011

Dr. M.P.Narmadha, John, J., N, M., and M, N., “Evaluation of Montelucast as add on therapy (corticosteroid sparing effect) to inhaled corticosteroids in patients with chronic persistent asthma.”, International journal of drug development & Research , vol. 3, no. 1, 2011.[Abstract]


WHO recognizes asthma as a disease of major public importance and stimulates research in to the causes of asthma to develop new control strategies and treatment techniques. Inhaled corticosteroid (ICS) used as first line preventive therapy is associated with systemic adverse events. The aim of the study was to improve patient care and therapeutic benefits by including montelukast along with ICS. The corticosteroid sparing properties of montelukast was studied and the efficacy of concomitant montelukast was evident in test group with FEVI value (2.16vs1.73) with improvement in mean day time score and mean asthma free days and reduction in ß agonist use & mean asthma exacerbation days.

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2011

Ravikumar, Dr. M.P.Narmadha, T, S., and M, T., “Evaluation of tolerability and efficacy of glucosamine with chondroitin in the treatment of knee osteoarthritis – a double blind multicentre randomized prospective comparative study ”, International journal of Applied Biology and Pharmaceutical Technology, vol. 2, no. 2, 2011.

2011

M. Jose, Abraham, A., and Dr. M.P.Narmadha, “Effect of silymarin in diabetes mellitus patients with liver diseases”, Journal of pharmacology & pharmacotherapeutics, vol. 2, pp. 287-9, 2011.[Abstract]


Previous studies have reported that silymarin reduces hepatic fibrosis via TGF-b1 and is associated with inhibiting glycogenolysis and gluconeogenesis through inactivation of the intrahepatic NF-kB signaling pathway (Jose et al., 2011). In the present study, we found that silymarin downregulated blood glucose level and significantly improved cardiac dysfunction in STZ-induced diabetic rats.

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2011

P. Amirthalingam and Dr. M.P.Narmadha, “Conversion of Intravenous-to-Oral Antimicrobial Therapy in South Indian Population”, International Journal of Research in Pharmaceutical and Biomedical Sciences, vol. 2, pp. 1258-1260, 2011.[Abstract]


In general, Mostly 48 hours free of fever following the start of IV antimicrobial therapy as an indication that “IV to Oral” switch may take place. In recent years many studies had advocated regimen of relatively short intravenous therapy i.e. for 2-3 days followed by oral treatment for the remaining course. The Objective of the Study was an assessment of the conversion based on the eligibility criteria and impact of the intervention provided. Methods: All the inpatients admitted to the study site during the study period in which the prescription should have at least one IV antimicrobial were included in the study. A prospective study was conducted at a 450-bedded multi specialty tertiary care private hospital for a period of 6 months in General medicine department. Results: The total number of patients admitted in the study site during the study period was found to be 126. Group I: General medicine, control (n=90), Group II: General medicine – intervention was provided (n=36). The average costs were Rs 2217 ± 1757 and Rs 1959 ± 2352 in Group I and Group II respectively. The average length of stay was 6.81 ± 2.69 and 6.21 ± 2.40 days in Group I and Group II respectively. Conclusion: The results demonstrated that clinical pharmacy activities, which can play a pivotal role when trying to influence and change the antimicrobial prescription (IV to Oral conversion) and also it, may reduce the cost on different departments in the hospital.

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2011

P. Amirthalingam, T., S., Uthirapathy, S., Dr. M.P.Narmadha, and Natham, R., “Antiepileptic drugs and cognitive impairment in epileptic patients at a private hospital”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 2, pp. 824-829, 2011.[Abstract]


Adverse effects of antiepileptic drugs are considered by patients to be at least as important as repetitive seizures in terms of quality of life. Antiepileptic drugs induced toxicity is frequent and contributes to a high proportion of treatment failures. Cognitive impairment is the common adverse effect seen with antiepileptic drugs that directly affects the quality of life of the patients. So it is important to compare the cognitive function of epileptic patients with antiepileptic drugs and without antiepileptic drugs. Study was carried out in 100 bedded Private Neuro hospital for the period of six months. All type of epileptic patients (ambulatory patients) was included in this study to compare Cognitive functions. Epileptic with any other co-morbid condition and Children (below 13yrs) and tumor were excluded from the study. Mini mental status examination and WAIS-R test has been performed in the study population. The total number of epileptic patients were included in the study site during study period were found to be 200.The study population divided into two groups i.e. Group A- Newly diagnosed epileptic patients and Group B- Epileptic patients with antiepileptic drug treatment. Gender distribution of the study population indicates a predominant male population in both Group A (58%) and Group B (56%). The average age of the overall study population was found to be 26.23±13.73 (13-65) years and 25.26 ±14.76 (13-64) in Group A and Group B respectively. The investigation was made to compare the cognitive level between Group A and Group B and the result indicates that poor cognitive performance by the Group B (Epileptic patients under treatment with Antiepileptic drugs for at least one year) and better cognitive performance by the Group A (Newly diagnosed Epileptic patients). P value is <0.001 in all Mini mental status examination and WAIS-R test. It shows there is significant difference between the Group A and Group B in Cognitive level. This study recommends that a systematic and careful monitoring of cognitive function should be performed in the management of epilepsy in order to achieve the quality of life in epileptic patients.

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2011

S. Uthirapathy, Dr. M.P.Narmadha, A, P., .T, S., N.N, R., and A, G. R., “Comparative Assessment of Cognitive Performance in Epileptic Patients with Antiepileptic Drug Treatment and Normal Healthy Volunteers”, The Journal of Pharmacy , 2011.[Abstract]


The objective of the proposed study was an a of adverse effects of anti epileptic drugs through the patient medication interview and a of Cognitive impairment. Study was carried out in 100 bedded Private neuro-hospital, Erode. All types of epileptic patients (ambulatory patients) and 100 healthy volunteers were included in this study to compare the cognitive level with the patients. Epileptic with any other co-morbid condition like head injury, stroke, trauma, congenital malfunctioning, mental sub normality, children (below 13yrs) and tumor were excluded from the study. The total number of epileptic patients (ambulatory patients) were interviewed in the study site during the study period were found to be 114. Gender distribution of the study population was given, which indicates a predominant male (58%) population. The average age of the overall study population was found to be 26.74±11.95 (13 to 65) years. The result shows that p with Complex partial seizure (24%) were extremely diagnosed at the study site. Phenytoin (46%) is majorly prescribed antiepileptic drug followed by Sodium valproate (36%), carbamazepine (32%), etc. Drowsiness is the commonly reported adverse effect (37%) followed by headache (15.57%), weight gain, alopecia, anorexia, etc. Mini mental status (MMSE scale) analysis revealed that half of the patient was 19 to 10scored (81%) followed by 20 to 22 scored (17%) etc. This indicates patient with epilepsy and/or anti epileptic therapy affect cognition. So the pharmacist can play a pivotal role in the management of epilepsy by monitoring the adverse effects, cognitive level by providing the guidelines to educate and motivate the patients regularly.

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2010

Dr. M.P.Narmadha and K, Tantony., “Nucleoside reverse transcriptase inhibitors induced Hyperlactatemia in HIV patients”, International Journal of Pharma Research, vol. 3(4), 2010.

2009

H. Ibrahim AR, J, B., R, S., LS, P., and Dr. M.P.Narmadha, “BA/BE calling;Attention Pharmacist ”, Pharma Review, vol. 07, 2009.[Abstract]


Thanks to the clinical research boom, Industry has witnessed many changes from economy to openings. The number of generic players has risen tremendously over years, which lead to the increased emergence of Bioavailability/Bioequivalence (BA/BE) clinical/contract research organizations (CROs). India, the home of most number of FDA approved manufacturing plants outside the US is now moving towards the generic revolution. With more products in the pipeline, the country is poised to consolidate her leading arm. Apart from the reduction of drug costs, generics increase drug use; prevent drug shortages; promote product rationalization and avoid supply disruption. Increased awareness of Good Clinical Practices (GCP) requirements, stronger desire of international acceptability of research done in India has brought favorable changes in the attitude of researchers in India towards human research. Like the multi-centric clinical trials, the number of CROs conducting BA/BE studies is increasing day by day offering plenty of opportunities to healthcare graduates/professionals, particularly for pharmacy graduates. The position in these CROs are promising and challenging with chances of conducting studies for various regulatory submissions. It gives the pharmacy professionals the much needed clinical experience in a country where the pharmacists are focused mainly on the industrial aspects. Transferable skills and the right attitude are much essential for a candidate to fetch an offer in this area. The profiles ranging from volunteer recruitment to report writing are discussed in this article.

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2009

B. Jeyaraj, Ibrahim, H., Goldfarb, N. M., and Dr. M.P.Narmadha, “Bioethics Education Online”, Journal of Clinical Research Best Practices, 2009.

2009

Dr. M.P.Narmadha, Nandhakumar, J., Sengottuvelu, S., Tyagi, M. G., Sethumathi, P. P., Karthikeyan, D., Vasudevan, M., Dr. M.P.Narmadha, and Sivakumar, T., “Efficacy, Tolerability, and Safety of a Multicomponent antiinflammatory With Glucosamine Hydrochloride vs Glucosamine Sulfate vs an NSAID in the Treatment of Knee Osteoarthritis—A Randomized, Prospective, Double-Blind, Comparative Study”, IMCJ( Integrative Medicine :A Clinician Journal( Innovisions publications), vol. 8, no. 3, 2009.

2009

Dr. M.P.Narmadha and jose, A., “Cardio–protective effect of polyherbal formulation in isoproterenol induced cardiotoxicity ”, International journal of Pharma Research, vol. 2(3), 2009.

2008

H. Ibrahim and Dr. M.P.Narmadha, “Clinical research education in India”, Journal of Clinical Research Best Practices, vol. 4(4), 2008.

2004

Dr. M.P.Narmadha and Subramanaian, T., “Advertisements on Antihypertensive drugs in Indian Medical Journals”, Asiatic Pacific congress-Hypertension, 2004.

2002

K. K. V. George, Nagarajan, M., and Dr. M.P.Narmadha, “A study on drug prescribing pattern in Madurai city”, Indian Journal of Pharmacology, vol. 34(5), 2002.[Abstract]


The effects of Bonny light crude oil on the smooth and skeletal muscles contraction and pain were investigated. Methods: Analgesic effect of Bonny light crude oil was tested in mice using acetic acid (0.75%)- induced writhing model. Its effects on histamine-, and Ach-induced smooth muscle contraction were studied in guinea pig ileum. The effects of crude oil on Ach-induced contraction of rat duodenum and frog rectus abdominis muscle were also studied. Results: The crude oil caused complete inhibition of histamine - induced smooth muscle contraction, while producing only a partial inhibition of the acetylcholine - induced contraction. It had no effects on the acetylcholine-induced skeletal muscle contraction, but showed good analgesic effect comparable to aspirin. Conclusion: The Bonny light crude oil possesses inhibitory action on smooth muscle contraction induced by histamine, and analgesic property.

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2001

Sundaramoorthy, N, N., and Dr. M.P.Narmadha, “Physiochemical and bioavailability studies of a drug in the presence of other drug. ”, The eastern pharmacist , 2001.

1996

Dr. M.P.Narmadha and .B.Jayswal, S., “Preparation and evaluation of Transdermal patches of salbutamol sulphate”, Eastern pharmacist, 1996.

Publication Type: Conference Paper

Year of Publication Title

2019

J. disilva, Salim, M., and Dr. M.P.Narmadha, “Correlation of Clinico-Bacterio Radiological Profile with Antitubercular Drug Treatment in Smokers and Nonsmokers Suffering From Pulmonray Tuberculosis”, in Saudi Journal Medicine Pharmacy , 2019.[Abstract]


Both tobacco smoking and tuberculosis are major global public health problems. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to find the association between smoking and pulmonary TB. Materials and methods: Pulmonary TB patients aged between 17 and 85 years were enrolled over a period of 9 months. All patients had two consecutive sputum smears examined for the presence of acid –fast bacilli (AFB) using Fluorescence Microscopy technique at the initiation of treatment and repeated as per recommendations of the RNCTP. Response was determined in terms of sputum conversion at the end of intensive phase and final treatment outcomes. Results: Out of total of 124 current smokers, a very high number of patients 83(66.7%)were found to have a high load of TB bacilli(3+), these smokers with sputum 3+ grade showed less response to TB drug treatment. Out of 83 patients, only 15 patients (18.7%) showed smear conversion at the end of intensive treatment. 45 patients who had cavitary disease , 30 (66%)patients had cleared at the end of IP and 15 patients showed persistence of cavitation in smokers while 76% of non smokers showed clearance of cavity(P<0.05). Cure rate among smokers, ex smokers and non smokers were 52.5%, 78% and 84%, respectively. Conclusion: Smokers during initial presentation, as well as at end of the treatment indicate more radiological findings, cavitary disease, and worse sputum AFB smear grading. Smokers also had a poorer outcome in terms of treatment success rate as compared to non smokers. This was largely due to high percentage of default rate among smokers implying treatment adherence issues among smokers as a main confounder to treatment success. Focus needs to be made to reduce defaulters which are more common among smokers.

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