Ph.D, MSc

Dr. Prasanna Ramani did his master’s degree in Chemistry from Bharathidasan University, India and Ph. D. in Chemical Sciences from University of Milan, Italy.

His doctoral thesis work was focused on Synthesis/labeling of Modified Peptide Nucleic Acids (artificial DNA) and their Analytical Properties. Dr. Ramani worked on polymer chemistry, total synthesis of natural products and functionalization of CNTs during his tenure as a postdoctoral researcher at Center for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy. His postdoctoral research was supported by UNESCO grant from University of Trieste, Italy.

Before his doctoral studies, Dr. Ramani worked for three years as Senior Chemist at Orchid Chemicals and Pharmaceuticals Ltd., Chennai, India. He has organized, participated and presented in various meetings and workshops around India and Europe.

Dr. Ramani is also guiding a number of undergraduate & postgraduate student projects and Ph. D. research scholars. He currently researches on synthesis of biologically interesting molecules and natural product chemistry.


December 2006 Doctoral Degree University of Milano, Italy
August 2000 Postgraduate Degree Bishop Heber College, Bharathidasan University, Trichy
July 1998 Undergraduate Degree Bishop Heber College, Bharathidasan University, Trichy


March 2009 – Present Assistant Professor (SG),   Department of Sciences, Amrita Vishwa Vidyapeetham
Sep 2006– Feb 2007  Research Associate, University of Milano, Italy.
Feb 2007 –Feb 2009 Post-doctoral fellow, Centre for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy
Sep 2000 – June 2003 Research Chemist, Orchid Chemicals and Pharmaceuticals Ltd., Chennai 


The research team targets on the synthesis of new molecules that can target cancer. Cancer results from mutation of certain genes that allow the cells to begin their uncontrolled growth. These mutations are inherited or acquired. The group members intend to find a possible solution towards cancer free world. The following are our Research interests:

  • Peptide Nucleic Acids:

The remarkable binding properties of ‘Peptide Nucleic Acids’ (PNA), the so called artificial DNAs, have spawned a rapidly expanding new field of research and their applications as therapeutics, DNA diagnostics, tools in biotechnology and much more. PNA is linked to various scientific disciplines, few includes medicinal chemistry, biochemistry, molecular biology, immunology and drug development. Our focus is to improve the solubility and sensitivity to detect complementary natural nucleobases. 

  • Medicinal Chemistry:

Endangered Plants:

Herbal medicines are assumed to be of great importance in the primary health care of individual and communities. The World Health Organization has estimated that 80% of the population of developing countries still relies on traditional medicines, mostly plant drugs, for the primary health care needs. The high degree of efficacy and safety with herbal medicines make them more acceptable compared to other therapeutic invention. Plant-based traditional knowledge has become a recognized tool in search for new sources of drugs and neutraceuticals. Our basic aim is to identify the plants which are on the verge of extinction and find the medicinal value of that plant, which can be used by us in our day today life.

Anti-Cancer molecules:

Alkaloids are a class of naturally occurring organic nitrogen containing compounds. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action on man or other animals. Alkaloids have potent anticancer activity against various cancers. Our intentions are to synthesis some alkaloids and study their biological properties.

  • Combinatorial chemistry:

In this, our research has been focused on the design and synthesis of small molecules towards human carcinoma. This work is in collaboration with Dr. Krishnan Namboori of Computational Chemistry Group. Molecules generated through computer-assisted molecular design will be screened for synthetic feasibility. Selected molecules will be synthesized in our laboratory and subjected to biological evaluation.

  • Drug Delivery:

 Sustained Drug Delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in human system as needed to safely achieve its desired therapeutic effect. This can be attained by maintaining a constant drug concentration for a specific period of time with minimum side effect. Most pharmaceutical drugs in the market are encapsulated with gelatin, which is manufactured from the collagen of animal skin or bone. The target in this research is to find an alternative means of encapsulating those drugs for sustained release.



Publication Type: Conference Paper

Year of Publication Title


N. Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “Synthesis, Antioxidant and Anti-inflammatory Studies of Substituted Chromene - A Preliminary Anti-Cancer study”, in Materials Today: Proceedings, 2018, vol. 5, pp. 16689-16694.[Abstract]

The target substituted chromene molecule 1 was prepared by a simple one pot synthesis using 3-chloro benzaldehyde, malononitrile and 3-(dimethylamino)phenol. The crude was purified using preparative TLC, preliminary biological evaluations such as in vitro anti-oxidant and anti-inflammatory studies were carried out. The IC50 value for the molecule (25.2μg/mL) was found to be good when compared with ascorbic acid (IC50 = 24.8μg/mL). The dimethyl amino group and presence of chlorine seems to be favorable for in vitro biological studies. The activities demonstrated by the compound suggest that it could be useful for anti-cancer studies and give way towards the synthesis other substituted chromenes. © 2017 Elsevier Ltd.

More »»

Publication Type: Journal Article

Year of Publication Title


Na Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies”, Journal of Heterocyclic Chemistry, vol. 53, no. 6, pp. 1778-1782, 2016.[Abstract]

A series of new 4-aryl-4H-chromene-3-carbonitrile derivatives were obtained by one-pot synthesis using substituted benzaldehydes, malononitrile, and substituted phenols. All the synthesized compounds (1a, 1b, 1c, 1d, 1e) were screened in vitro for antioxidant and anticancer activities. Compounds 1c, 1d, 1e showed significant antioxidant activity in nitric oxide free radical scavenging method while compounds 1c and 1e showed significant activity in hydrogen peroxide free radical scavenging method. The other compounds showed significant to moderate activities in both the methods in comparison with ascorbic acid and butylated hydroxytoluene as standards. Compounds 1c, 1d, 1e exhibited good anticancer activity, using Michigan Cancer Foundation-7 (MCF-7) cell line, compared with those of other synthesized compounds. © 2015 HeteroCorporation.

More »»


K. Silpa, Shilpa, G. S., and Dr. Prasanna Ramani, “Applications of Fluorescent Makers”, J. Environ. Nanotechnol, vol. 4, pp. 16–18, 2015.


Dr. Prasanna Ramani, Vijith, V. S., Harikrishnan, K. V., Krishnapriya, S., Varma, V., Jose, A., Kumar, E. P., and P.K., K. Namboori, “Design of Novel Drug Molecules for the Treatment of Breast Cancer”, International Journal of Pharmaceutical Sciences Review and Research, 2013.


Dr. Prasanna Ramani and Fontana, G., “A new synthetic approach to 7-hydroxynitidine”, Tetrahedron Letters, vol. 49, pp. 5262 - 5264, 2008.[Abstract]

Benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized from readily available 2-benzyloxy-6-bromo-3,4-dimethoxybenzaldehyde 5 and napthylamine 6 using reductive amination followed by radical cyclization in eight steps. This method is highly efficient and better way to synthesize fully aromatized benzo[c]phenanthridine compounds.

More »»


C. Baldoli, Dr. Prasanna Ramani, Oldani, C., Licandro, E., Valerio, A., Ferruti, P., Falciola, L., and Mussini, P., “Synthesis of new water soluble electrochemically active probes for biomolecules”, 2007.


C. Baldoli, Oldani, C., Licandro, E., Dr. Prasanna Ramani, Valerio, A., Ferruti, P., Falciola, L., and Mussini, P., “Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules”, Journal of Organometallic Chemistry, vol. 692, pp. 1363 - 1371, 2007.[Abstract]

Carboxy-terminated polyvinylpyrrolidin-2-one (PVP) has been used as a new water-soluble and biocompatible polymeric support for a series of ferrocene labeled amino acid and peptide nucleic acid (PNA) monomer derivatives 4–7. The organometallic polymer-conjugates thus obtained are new and potentially useful as water-soluble electrochemically active probes for biomolecules. In view of such application, their electrochemical activity has been evaluated and has proved very high notwithstanding the complexity and bulkiness of the molecule, affording detection limits down to 10−8 M in the aqueous medium.

More »»


Dr. Prasanna Ramani, Baldoli, C., Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Rigamonti, C., and Zinzalla, G., “A new ferrocene Conjugated of a tyrosine PNA monomer synthesis and electrochemical properties”, Journal of Organometallic Chemistry, 2004.


C. Baldoli, Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Dr. Prasanna Ramani, Rigamonti, C., and Zinzalla, G., “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties”, Journal of Organometallic Chemistry, vol. 689, pp. 4791 - 4802, 2004.[Abstract]

A new chiral ferrocene-labelled tyrosine PNA monomer 1 has been synthesised in good yield in both racemic and enantiomerically pure forms. It is suitable for insertion in various positions of PNA oligomers, a possibility that has been preliminarily demonstrated by synthesising the dimer 16. Moreover, in view of possible applications to nucleic acid detection, a preliminary voltammetric investigation on the electrochemical activity of monomer 1 and its synthetic precursors has been carried out in DMF. It appears that, despite the bulkiness of the PNA monomer backbone, its insertion on the ferrocene group only moderately lowers the latter’s diffusion coefficients and peak currents, thus affording voltammetric detection limits in the order of 10−6–10−7 M.

More »»

Publication Type: Patent

Year of Publication Title


Dr. Prasanna Ramani and PK, K. Namboori, “Methods and Formulations for Screening and Treatment of Prostate Cancer”, U.S. Patent 5417/CHE/20152015.

Publication Type: Conference Proceedings

Year of Publication Title


S. K, G.S, S., and Dr. Prasanna Ramani, “Applications Of Markers”, Recent trends in Medicinal Chemistry. 2015.


A. Rajan K.V, Dr. Prasanna Ramani, and S, S. G., “Role of pyrrole in biological systems”, Recent trends in Medicinal Chemistry. 2015.


Dr. Prasanna Ramani, K, P., S, S., K, R., and S, G., “Synthesis and Analysis of Efficient Drug Delivery System using Sulphonated-Polyetheretherketone”, 2nd International Conference on Emerging Trends in Chemical and Pharmaceutical Sciences. 2014.


P. E.R, Dr. Prasanna Ramani, Arun M, R, A. Swaminatha, S.M, M. Vishwanath, Rangarajan, M., and Kothurkar, N., “Synthesis of zeolites using polyethylene glycol as binder for biological applications”, Emerging Trends in Drug Discovery – AICADD 2014. Amrita Vishwa Vidyapeetham, Coimbatore, 2014.

Publication Type: Book Chapter

Year of Publication Title


Dr. Prasanna Ramani, “Peptide Nucleic Acids and Markers”, in Academic Publishers, 2011.

Peer Reviewed International Journals (Under Review)

  1. Sathianarayanan, S., Amrutha B Chittethu, Asha Jose, Ranganathan, B., Saranya, T.S, Asha Asokan, M., Ramani. P., “Design And Synthesis Of Isatin Semicarbazone Derivatives Against Mammary Carcinoma Cells”, Medicinal Chemistry Research (Under Review); IF: (1.6)
  2. Nancy Thomas, Subin Mary Zachariah, Ramani. P., “4-Aryl-4H-chromene-3-carbonitrile derivates: Synthesis and preliminary anti-breast cancer studies”, Journal of Heterocyclic Chemistry, (Accepted); IF: (0.8)
  3. Athira Rajan K.V, Shilpa G. S, Ramani. P., “ Biological Importance Of Pyrrole”, Journal of Environmental Nanotechnology (Accepted); IF: (0.6)
  4. Silpa K, Ramani. P., Shilpa G.S., “Applications Of Fluorescent Makers”, Journal of Environmental Nanotechnology (Accepted); IF: (0.6)
  5. Pavithra E.R, Arun M, Anirudh Swaminathan R, Muthubalaji Vishwanath S.M, Murali Rangarajan, Nikhil Kothurkar, Ramani. P., “Synthesis of zeolites using polyethylene glycol as binder for biological applications”, Procedia Chemistry, (Accepted); 
  6. Nancy Thomas, Subin Mary Zachariah, Ramani. P., “Synthesis, Anti-Oxidant and Anti-Inflammatory Studies Of Substituted Chromene – A Preliminary Anti-Cancer Study”, Procedia Chemistry, (Accepted)

Reviewer – Journals  

  • Tetrahedron Letters – Elsevier,
  • Bio-organic and medicinal chemistry – Elsevier,
  • Journal of heterocyclic chemistry – Springer,
  • Journal of Advanced Pharmaceutical Technology and Research – Medknow,

Other Academic/Non-Academic Activities

  1. Member, Board of Studies, Five-year Integrated M.Sc Chemistry, Department of Sciences, Amrita Vishwa Vidyapeetham.


  1. Awarded “Recognized reviewer Status” from Elsevier
  2. Young scientist award received from Department of Science and Technology, India (2013).
  3. Recipient of UNESCO grant in collaboration with ICTP to pursue Post-doctoral research at CISI, Univ. of Milan, Italy (Feb 07 – Feb 09).
  4. Recipient of grant to work as a “Research Associate” from University of Bari, Italy (Sep06—Feb07)
  5. Young researcher award at ―XXX “A. Corbella” Summer School held at Gargnano, Italy (June 2005)
  6. Italian Chemical Society (SCI) grant to participate at the ―First Austrian—German— Italian meeting of Organic Chemistry held at Vienna, Austria (April 2005)
  7. Member of Italian Chemical Society (SCI) since 2003
  8. Awarded financial assistantship in Non-EU category by University of Milan, Italy, for pursuing Doctoral research (2003—2006).

Membership in Professional Bodies

  1. Italian Chemical Society (SCI) since 2003

Teaching (PG/PhD Courses)

  • PG Course 3
  • PhD Course 3

Student Guidance

Doctoral Students

  1. Development of Modified and Labeled Peptide Nucleic Acid Oligomers for DNA Recognition”, Shilpa G.S. Ongoing  
  2. Modified Arecoline Derivatives: Synthesis and Preliminary Anti-Cancer Studies”, Baladhandapani A. Ongoing

Master’s Students

  1. Design, Synthesis and Biological Evaluation of Anti-Prostate Cancer Agents”, Harikrishnan K. V (M.Pharm), 2013.
  2. Fragment Based Drug Design, Synthesis and Evaluation of Anti-Cancer Drugs Targeted on Breast Cancer Proteins”, Vijith V.S (M.Pharm), 2013.
  3. “Synthesis of 3-isopropyl-2-methoxymethyl pyrrole for anti-pancreatic cancer”, Athira Rajan K.V (M.Sc), 2015
  4. “Synthesis of Labeled Peptide Nucleic Acid Monomers and its analytical studies”  Silpa K (M.Sc), 2015

Bachelor’s Students (B.Tech)

  1. “Design, Synthesis and Biological Analysis of modified Arecoline”, Kirti G Pillai, Varun S K, Department of Chemical Engineering and Material Sciences, 2014.
  2. “Continuous Pyrolysis of Plastic in a Catalytic Fixed Bed Reactor”, Anirudh S., Arun M., Muthubalaji Vishwanath S.M., Pavithra E.R., 2014 (Dr. Murali Rangarajan, Dr. Nikhil Kothurkar, Dr. Udaya Baskar Reddy Ragula).
  3. “Novel Pathway To Synthesise Key Intermediate To Benzophenanthridines: Photoreduction Of Nitro Naphthalenes”, Atulya Varma, Himanshu Goyal, Manoj Sundar C. A., Department of Chemical Engineering and Material Sciences, 2012.
  4. Synthesis and modelling of Labelled Peptide Nucleic Acids”, Sharmila S, Sindhura Reddy N, Sre Vinojaa T, Nandhini M, Department of Chemical Engineering and Material Sciences, 2011.

Conferences/Seminar/Guest Lecture

  • Participated as a Resource Person in a One Day National Seminar on Spectral Analysis in Pharmaceutical Research was organized at Amrita School of Pharmacy on March 22, 2010.
  • Given a Lecture on Overview of NMR Spectroscopy and Interpretation, at Amrita School of Pharmacy on Feb 22-23, 2010.
  • Lecture on Microwave in Organic Synthesis given at Avinashilingam University, Coimbatore.

Workshop Attended

  • Participated in an International Workshop on Solid State NMR, Organized by TIFR- RAC- Ooty during Jan 4- 8, 2010.