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Phthalimido protected peptide nucleic acid monomer – Synthesis and Characterization

Publication Type : Conference Paper

Thematic Areas : Advanced Materials and Green Technologies

Publisher : Materials Today: Proceedings

Source : Materials Today: Proceedings, Elsevier Ltd, Volume 5, Number 8, p.16580-16584 (2018)

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Campus : Coimbatore

School : School of Engineering

Center : Center for Excellence in Advanced Materials and Green Technologies

Department : Chemical, Civil

Year : 2018

Abstract : pGlycine based peptide nucleic acid (PNA) monomers are useful in the construction of PNA oligomers which are, in general, hydrophobic in nature. To overcome this huddle, serine based peptide nucleic acid (PNA) monomer was synthesized which will a good candidate in terms of increasing hydrophilicity. The synthesis involves in the alkylation of N-bromoethyl phthalimide on nosyl protected serine methyl ester followed by deprotection and condensation with nucleobase yields PNA monomer. The phthalimide group on nitrogen serves as protecting group as well as marker. © 2017 Elsevier Ltd./p

Cite this Research Publication : S. Sivakumar, Ramani, P., and Shilpa, G. S., “Phthalimido protected peptide nucleic acid monomer - Synthesis and Characterization”, in Materials Today: Proceedings, 2018, vol. 5, pp. 16580-16584.

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