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Synthesis, Antioxidant and Anti-inflammatory Studies of Substituted Chromene – A Preliminary Anti-Cancer study

Publication Type : Conference Paper

Publisher : Elsevier Ltd

Source : Materials Today: Proceedings, Elsevier Ltd, Volume 5, Number 8, p.16689-16694 (2018)

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Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis, Sciences

Year : 2018

Abstract : The target substituted chromene molecule 1 was prepared by a simple one pot synthesis using 3-chloro benzaldehyde, malononitrile and 3-(dimethylamino)phenol. The crude was purified using preparative TLC, preliminary biological evaluations such as in vitro anti-oxidant and anti-inflammatory studies were carried out. The IC50 value for the molecule (25.2μg/mL) was found to be good when compared with ascorbic acid (IC50 = 24.8μg/mL). The dimethyl amino group and presence of chlorine seems to be favorable for in vitro biological studies. The activities demonstrated by the compound suggest that it could be useful for anti-cancer studies and give way towards the synthesis other substituted chromenes. © 2017 Elsevier Ltd.

Cite this Research Publication : cited By 0; Conference of 2016 International Conference on Advanced Materials, SCICON 2016 ; Conference Date: 19 December 2016 Through 21 December 2016; Conference Code:138807

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