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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Ann Transplant
Source : Ann Transplant, Volume 22, p.499-506 (2017)
Keywords : adult, Age Factors, Clinical Decision-Making, end stage liver disease, female, Humans, liver transplantation, Living Donors, male, middle aged, Prognosis, Retrospective Studies, Risk Factors, Transplant Recipients
Campus : Kochi
School : School of Medicine
Department : Gastrointestinal Surgery
Year : 2017
Abstract : BACKGROUND Recipient outcomes in adult living donor liver transplantation depend on various characteristics in both recipient and donor. We aimed to derive a score based upon preoperative characteristics in donor and recipient that could predict the recipient mortality in adult living donor liver transplantation. MATERIAL AND METHODS Retrospective data of 100 living donor liver transplantation recipients and their respective donors were analyzed for preoperative factors that correlated with recipient mortality. Statistically significant factors were weighted appropriately to derive a regression equation to obtain a donor-to-recipient match (DORMAT) score. This score was applied to 71 patients prospectively and their outcome was analyzed. RESULTS Donor-recipient match (DORMAT) score, derived using regression analysis of the significant variables was [0.002 (Recipient age) + 0.013 (Recipient BMI) + 0.055 (SBP) + 0.344 (HRS) + 0.022 (Pre-op culture positivity) + 0.01 (Donor age) - 0.639]×100. DORMAT score, when validated to a prospective cohort of 71 adult-to-adult LDLT patients, had a C-statistic (area under ROC curve) of 0.712. The mortality rate was seen to increase with increasing DORMAT score. CONCLUSIONS DORMAT score is a useful clinical decision-making tool to predict recipient mortality in adult living donor liver transplantation.
Cite this Research Publication : R. Babu, Sethi, P., Surendran, S., Dhar, P., Gopalakrishnan, U., Dinesh Balakrishnan, Ramachandran Narayana Menon, Thankamonyamma, B. Sivasankar, Vayoth, S. Othiyil, and Thillai, M., “A New Score to Predict Recipient Mortality from Preoperative Donor and Recipient Characteristics in Living Donor Liver Transplantation (DORMAT Score).”, Ann Transplant, vol. 22, pp. 499-506, 2017.