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Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: Report of two cases

Publication Type : Journal Article

Publisher : BMJ Case Reports

Source : BMJ Case Reports, Volume 14, Issue 4, 28 April 2021, Article number e240046

Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-85105082684&partnerID=MN8TOARS

Campus : Kochi

School : School of Medicine

Department : Respiratory Medicine, Rheumatology

Year : 2021

Abstract : Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. We describe two cases of myositis-associated rapidly progressive interstitial lung disease (RP-ILD). The patients were two women from Kerala, India. Both patients had anti-MDA5 antibody-positive myositis. Both patients presented with RP-ILD without any clinical features of myositis and succumbed to their illness despite aggressive medical treatment. Anti-MDA5-antibody-positive DM is characterised by amyopathic disease with rapidly progressive and fatal ILD. ©

Cite this Research Publication : Asmita A Mehta, Tisa Paul, Mithun CB, Nithya Haridas, "Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases," BMJ Case Reports, Volume 14, Issue 4, 28 April 2021, Article number e240046

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