Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Chitosan for Biomaterials IV: Biomedical Applications, Springer International Publishing,
Source : Chitosan for Biomaterials IV: Biomedical Applications, Springer International Publishing, (Advances in Polymer Science) Cham, p.411 - 446 (2021)
Url : https://link.springer.com/chapter/10.1007/12_2021_102
ISBN : 9783030830212
Keywords : chitosan, Microneedles, microsphere, Nanocarriers, Transdermal drug delivery
Campus : Kochi
School : Center for Nanosciences, School of Pharmacy
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine, Pharmacology
Year : 2021
Abstract : Chitosan is a natural polymer having much use in drug delivery applications. The polymer is characterized by its biocompatibility, biodegradability, muco-adhesiveness, antimicrobial activity, non-toxicity and positive charge. Insolubility of chitosan in water and other common organic solvents limits its utility. This problem can be solved by chemical modification of its reactive functional groups; NH2 and –OH to form derivatives with improved solubility. The transdermal drug delivery systems which can control the drug release process have got substantial importance in drug delivery research areas. Chitosan and its derivatives are reported to enhance the skin permeability via a variety of molecular mechanisms. Low molecular weight chitosan is often employed as permeability enhancer in transdermal drug delivery system (TDDS). Various chitosan based transdermal drug delivery systems like composite films, vesicular systems, dendrimers, microspheres, microneedles and other nanocarriers like nanoparticles, nanogel, nanoemulsion, nanolipid carriers with benefits achieved are detailed in this review.
Cite this Research Publication : Rajitha Panonnummal, Vrinda S. Kumar, Dr. Jayakumar Rangasamy, and Dr. Sabitha M., “Application of Chitosan and Its Derivatives in Transdermal Drug Delivery”, Chitosan for Biomaterials IV: Biomedical Applications, (Advances in Polymer Science) pp. 411 - 446, 2021.