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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Biological Macromolecules
Source : International Journal of Biological Macromolecules, Volume 45, Number 3, p.260 - 264 (2009)
Keywords : Bioactivity, Biomaterials, Cell studies, Chitin hydrogel, Chitin membranes
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2009
Abstract : Chitin is a novel biopolymer and has excellent biological properties such as biodegradation in the human body and biocompatible, bioabsorable, antibacterial and wound healing activities. In this work, α- and β-chitin membranes were prepared using α- and β-chitin hydrogel. The bioactivity studies were carried out using these chitin membranes with the simulated body fluid solution (SBF) for 7, 14 and 21 days. After 7, 14 and 21 days the membranes were characterized using SEM, EDS and FT-IR. The SEM, EDS and FT-IR studies confirmed the formation of calcium phosphate layer on the surface of the both chitin membranes. These results indicate that the prepared chitin membranes were bioactive. Cell adhesion studies were also carried out using MG-63 osteoblast-like cells. The cells were adhered and spread over the membrane after 24h of incubation. These results indicated that the chitin membranes could be used for tissue-engineering applications.
Cite this Research Publication : Dr. Jayakumar Rangasamy, Rani, V. V. Divya, Shalumon, K. T., Kumar, P. T. Sudheesh, Nair, S. V., Furuike, T., and Tamura, H., “Bioactive and osteoblast cell attachment studies of novel α- and β-chitin membranes for tissue-engineering applications”, International Journal of Biological Macromolecules, vol. 45, pp. 260 - 264, 2009.