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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Indian Journal of Experimental Biology
Source : Indian Journal of Experimental Biology, Volume 48, p.265-268 (2010)
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2010
Abstract : Aryl hydrazine and hydrazide analogues were synthesized based on p-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus, and tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. The synthesized analogues were tested for anticancer activity using NCI protocol. Anolgues 12 and 15 emerged as molecules with significant in vitro anticancer activity. Molecular docking study revealed the binding orientations of aryl hydrazines and hydrazides analogues in the active sites of thymidylate synthase.
Cite this Research Publication : Dr. Gopi Mohan C., SK, A., AK, S., and D, G., “Biological Evaluation and Molecular Docking of Aryl Hydrazines and Hydrazides for Anticancer Activity”, Indian Journal of Experimental Biology, vol. 48, pp. 265-268, 2010.