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Chemical constituents from Chonemorpha fragrans roots and antibacterial activity studies of sarcorucinine D

Publication Type : Journal Article

Publisher : Natural Product Research

Source : Natural Product Research, DOI: 10.1080/14786419.2021.1910263

Url : https://pubmed.ncbi.nlm.nih.gov/35635050/

Campus : Amritapuri

School : School of Biotechnology

Department : biotechnology

Year : 2021

Abstract : Nine non-alkaloid constituents viz., sitostenone (1), β-sitosterol (2), naringenin (3), aromadendrin (4), matairesinol (5), vanillic acid (6), ferulic acid (7), protocatechuic acid (8) and sitosterol-3-O-β-D-glucopyranoside (9) were isolated from the acetone extract as well as five alkaloids viz., japindine (10), sarcorucinine D (11), dictyophlebin (12), chonemorphine (13) and N-formylchonemorphine (14) were isolated from the ethanol extract of Chonemorpha fragrans roots. Except β-sitosterol, all other non-alkaloid compounds and the alkaloid sarcorucinine D are being reported for the first time from C. fragrans. From the MIC and MBC values, it has been found that sarcorucinine D shows most promising antibacterial activity. Quantification of antibacterial activity as well as killing curve determinations were performed in order to confirm the efficacy of the compound. The cytotoxic activity studies revealed that it is nontoxic up to 100 µM concentration.

Cite this Research Publication : Chemical constituents from Chonemorpha fragrans roots and antibacterial activity studies of sarcorucinine D (2021), Dhanya SR, Nair MS, Dileep Kumar BS & Vandana Sankar: Natural Product Research, DOI: 10.1080/14786419.2021.1910263 (IF 2.86)

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