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Cyclodextrin in drug delivery

Publication Type : Book Chapter

Publisher : Elsevier

Source : Book Title: Natural Biopolymers in Drug Delivery and Tissue Engineering. Publisher: Elsevier (Under Revision).

Url : https://pubmed.ncbi.nlm.nih.gov/16296758/#:~:text=In%20the%20pharmaceutical%20industry%20cyclodextrins,increase%20their%20bioavailability%20and%20stability.

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis

Year : 2005

Abstract : Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrin molecules are relatively large with a number of hydrogen donors and acceptors and, thus, in general they do not permeate lipophilic membranes. In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs, and to increase their bioavailability and stability. Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. However, the addition of cyclodextrins to existing formulations without further optimisation will seldom result in acceptable outcome. Currently there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrin complexes on the market.

Cite this Research Publication : Anju J, Sreeja V, Prashant Sadanandan, Athira K V. Cyclodextrin in drug delivery. Book Title: Natural Biopolymers in Drug Delivery and Tissue Engineering. Publisher: Elsevier (Under Revision).

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