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Design of Chalcones of 7-Azaindole as Raf-B Inhibitors

Publication Type : Journal Article

Publisher : Journal of Advanced Chemical Sciences

Source : Journal of Advanced Chemical Sciences, Volume 4, p.606-608 (2019)

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Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis

Year : 2019

Abstract : The present work deals with the design of 7-azaindole derivatives for its Raf-B inhibition. All the designed compounds follows Lipinski’s rule of five. In silico ADME predictions of all the designed compounds suggests that none of the compounds have problem with bioavailability. The compounds were designed on the binding affinity towards the Raf-B inhibition. It was observed that few of the designed compounds were found to have significant interaction with the active site of the receptor. The compounds possessing 3-hydroxyl-2-methyl as substitution in chalcone was found to possess maximum docking score than other designed compounds.

Cite this Research Publication : D. Giles, Dr. Saiprabha N, and Yeshna, G., “Design of Chalcones of 7-Azaindole as Raf-B Inhibitors”, Journal of Advanced Chemical Sciences, vol. 4, pp. 606-608, 2019.

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