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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Journal of Biomedical Nanotechnology
Source : Journal of Biomedical Nanotechnology, Volume 9, Number 7", publication date ="2013-07-01T00:00:00, p.1299-1305 (2013)
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2013
Abstract : This work explains about the development of a unique tubular scaffold for vascular tissue engineering. The inner layer/layers was made up of aligned poly (lactic acid) (PLA) nano fibers and outer layers were composed of random multiscale fibers of poly(caprolactone) (PCL)/PLA providing larger pores for Smooth Muscle Cell (SMC) penetration. The fabricated scaffolds were characterized by SEM. Cell attachment and infiltration studies using SMCs on the multiscale fibers were characterized by SEM and confocal microscopy. Blood compatibility of the scaffold was analysed by haemolysis-coagulation assays, platelet activation studies and the effect of material/fiber alignment on the morphological stability of Red Blood Cells (RBCs) were evaluated using SEM. Since this hierarchically designed tubular scaffold closely mimics the morphology of native vessel, this could be a better candidate for vascular tissue engineering.
Cite this Research Publication : K. T. Shalumon, Chennazhi, K. P., Nair, S. V., and Dr. Jayakumar Rangasamy, “Development of Small Diameter Fibrous Vascular Grafts with Outer Wall Multiscale Architecture to Improve Cell Penetration”, Journal of Biomedical Nanotechnology, vol. 9, pp. 1299-1305, 2013.