Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Indian Journal of Geo-Marine Sciences, National Institute of Science Communication and Information Resources (NISCAIR)
Source : Indian Journal of Geo-Marine Sciences, National Institute of Science Communication and Information Resources (NISCAIR), Volume 49, Number 5, p.379-385 (2012)
Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-84924276943&partnerID=40&md5=815330d2a01b1bd322dec77f56f73291
Keywords : Mus, Vitaceae, Vitis vinifera
Campus : Kochi
School : School of Medicine
Department : Biochemistry
Year : 2012
Abstract : Ethanol metabolism is known to induce overwhelming production of reactive oxygen species (ROS) and also to cause associated immune dysfunction. Several interventional agents of plant origin, in particular fruits and vegetables have been used to counteract these alterations induced by ethanol. In this study, we investigated the efficacy of dietary feeding of skin and flesh of grapes (Vitis vinifera L.) on the alterations in immune and vascular functions in mice with liver abnormalities induced by chronic ethanol consumption. Results revealed that feeding of both grape skin and flesh (2.5 g/kg body wt/day) effectively attenuated the oxidative stress and alterations in immune function and angiogenesis induced by chronic ethanol consumption (1.6 g/kg body wt/day for 12 weeks) in mice. The antioxidant actions of the grape skin and flesh as observed in this study might be attributed to the polyphenols present in the grapes. © 2012, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Cite this Research Publication : S. Mukherjee, Dr. Damodaran Vasudevan, and Das, S. K., “Dietary grapes (vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice”, Indian Journal of Geo-Marine Sciences, vol. 49, pp. 379-385, 2012.